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    Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy

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    JCO-2016-Nyame-1345-9.pdf
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    Author
    Nyame, Y. A.
    Murphy, A. B.
    Bowen, D. K.
    Jordan, G.
    Batai, K.
    Dixon, M.
    Hollowell, C. M. P.
    Kielb, S.
    Meeks, J. J.
    Gann, P. H.
    Macias, V.
    Kajdacsy-Balla, A.
    Catalona, W. J.
    Kittles, R.
    Show allShow less
    Affiliation
    Univ Arizona
    Issue Date
    2016-02-22
    Keywords
    CANCER PREVENTION TRIAL
    LOW-RISK
    ACTIVE SURVEILLANCE
    AFRICAN-AMERICAN
    ANTIGEN LEVELS
    LNCAP CELLS
    BIOPSY
    CALCITRIOL
    OUTCOMES
    D-3
    
    Metadata
    Show full item record
    Publisher
    AMER SOC CLINICAL ONCOLOGY
    Citation
    Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy 2016, 34 (12):1345 Journal of Clinical Oncology
    Journal
    Journal of Clinical Oncology
    Rights
    © 2016 by American Society of Clinical Oncology
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Purpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low-or intermediate-risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study was to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin D (25-OH D) levels. Methods This cross-sectional study was carried out from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer screening. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extraprostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results Eighty-seven men (45.8%) in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (interquartile range, 59.0 to 67.0). On univariate analysis, men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 v 27.0 ng/mL, P = .007) compared with their counterparts. On multivariate analysis, controlling for age, serum prostate specific antigen, and abnormal digital rectal examination, serum 25-OH D less than 30 ng/mL was associated with increased odds of adverse pathology (odds ratio, 2.64; 95% CI, 1.25 to 5.59; P = .01). Conclusion Insufficiency/deficiency of serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study. (C) 2016 by American Society of Clinical Oncology
    Note
    "6 months embargo"
    ISSN
    0732-183X
    1527-7755
    DOI
    10.1200/JCO.2015.65.1463
    Version
    Final published version
    Sponsors
    Supported by a grant from the US Department of Defense W81XWH-10-1-0532 pd22E (A.B.M.), and the following National Institutes of Health grants: 1R01MD007105-01 (R.K.); IK2CX000926-01 (A.B.M.), and P50 CA090386-10S1 (W.J.C.).
    Additional Links
    http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.65.1463
    ae974a485f413a2113503eed53cd6c53
    10.1200/JCO.2015.65.1463
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