Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.
AuthorHarryman, William L
Little, Andrew S
Eschbacher, Jennifer M
Nagle, Raymond B
Cress, Anne E
AffiliationUniv Arizona, Ctr Canc
MetadataShow full item record
PublisherE-CENTURY PUBLISHING CORP
CitationLaminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. 2016, 8 (2):940-54 Am J Transl Res
RightsCreative Commons Attribution Non-Commercial License
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractThe laminin-binding integrin (LBI) family are cell adhesion molecules that are essential for invasion and metastasis of human epithelial cancers and cell adhesion mediated drug resistance. We investigated whether copy number alteration (CNA) or mutations of a five-gene signature (ITGB4, ITGA3, LAMB3, PLEC, and SYNE3), representing essential genes for LBI adhesion, would correlate with patient outcomes within human epithelial-type tumor data sets currently available in an open access format.
VersionFinal published version
SponsorsThe use of the Tissue Acquisition and Molecular Analysis Support Service (TACMASR) of the UA Cancer Center was essential for this work. Of particular note was the expert technical assistance of Ed Abril. The work was supported in part by CA P30 23074, CA164484 and CA159406.
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