Author
Ashktorab, HassanAhuja, Sadhna
Kannan, Lakshmi
Llor, Xavier
Nathan, Ellis
Xicola, Rosa M.
Adeyinka, Laiyemo O.
Carethers, John M.
Brim, Hassan
Nouraie, Mehdi
Affiliation
Univ Arizona, Ctr Canc, Canc Biol Res ProgramIssue Date
2014-11-09
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IMPACT JOURNALS LLCCitation
A meta-analysis of MSI frequency and race in colorectal cancer 2014 OncotargetJournal
OncotargetRights
Copyright © The Author(s), licensed under a Creative Commons Attribution 3.0 License.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
PURPOSE: African Americans (AA) are at a higher risk of colorectal cancer (CRC) and some studies report a higher frequency of microsatellite instability (MSI) in this population while others report lower frequency compared to Caucasians. AIM: To determine and evaluate the association of race and clinical factors with MSI frequency through meta-analysis. METHODS: Twenty-two studies out of 15,105 (1997-2015) were evaluated after a search in different literature databases, using keywords "colorectal cancer, microsatellite instability, African Americans, Caucasians and Hispanics". We used random effect meta-analysis to calculate the MSI frequency in all studies as well as in African American and Caucasian samples. Meta-regression analysis was used to assess the univariate effect of race, gender, age, tumor location and stage on MSI frequency. RESULTS: The overall MSI frequency among CRCs was 17% (95% CI: 15%-19%, I-2 = 91%). In studies with available race data, The MSI rate among AAs, Hispanics and Caucasians were 12%, 12% and 14% respectively and was not significantly different. Sub-group analysis of studies with racial information indicates MSI OR of 0.78 for AAs compared to Caucasians. CONCLUSION: CRCs demonstrate an overall MSI frequency of 17%. MSI frequency differences between AAs and Caucasians were not pronounced, suggesting that other factors contribute to the racial disparity. The methodological approaches and biological sources of the variation seen in MSI frequency between different studies need to be further investigated.ISSN
1949-2553Version
Final published versionSponsors
National Institute of Minority Health and Health Disparities; National Cancer Institute [G12MD007597, U01CA162147, R01CA206010]Additional Links
http://www.oncotarget.com/abstract/8945ae974a485f413a2113503eed53cd6c53
10.18632/oncotarget.8945
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Except where otherwise noted, this item's license is described as Copyright © The Author(s), licensed under a Creative Commons Attribution 3.0 License.