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    Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.

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    jn.00948.2015.full.pdf
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    Author
    Mazade, Reece E
    Eggers, Erika D
    Affiliation
    University of Arizona, Departments of Physiology and Biomedical Engineering
    Issue Date
    2016-06-01
    
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    Show full item record
    Publisher
    AMER PHYSIOLOGICAL SOC
    Citation
    Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling. 2016, 115 (6):2761-78 J. Neurophysiol.
    Journal
    Journal of neurophysiology
    Rights
    Copyright © 2016 by the American Physiological Society.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The retina adjusts its signaling gain over a wide range of light levels. A functional result of this is increased visual acuity at brighter luminance levels (light adaptation) due to shifts in the excitatory center-inhibitory surround receptive field parameters of ganglion cells that increases their sensitivity to smaller light stimuli. Recent work supports the idea that changes in ganglion cell spatial sensitivity with background luminance are due in part to inner retinal mechanisms, possibly including modulation of inhibition onto bipolar cells. To determine how the receptive fields of OFF cone bipolar cells may contribute to changes in ganglion cell resolution, the spatial extent and magnitude of inhibitory and excitatory inputs were measured from OFF bipolar cells under dark- and light-adapted conditions. There was no change in the OFF bipolar cell excitatory input with light adaptation; however, the spatial distributions of inhibitory inputs, including both glycinergic and GABAergic sources, became significantly narrower, smaller, and more transient. The magnitude and size of the OFF bipolar cell center-surround receptive fields as well as light-adapted changes in resting membrane potential were incorporated into a spatial model of OFF bipolar cell output to the downstream ganglion cells, which predicted an increase in signal output strength with light adaptation. We show a prominent role for inner retinal spatial signals in modulating the modeled strength of bipolar cell output to potentially play a role in ganglion cell visual sensitivity and acuity.
    Note
    Published 24 February 2016; final publication 1 June 2016. 12 month embargo.
    ISSN
    1522-1598
    PubMed ID
    26912599
    DOI
    10.1152/jn.00948.2015
    Version
    Final accepted manuscript
    Additional Links
    https://jn.physiology.org/content/115/6/2761
    ae974a485f413a2113503eed53cd6c53
    10.1152/jn.00948.2015
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