Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.
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Final Accepted Manuscript
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University of Arizona, Departments of Physiology and Biomedical EngineeringIssue Date
2016-06-01
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AMER PHYSIOLOGICAL SOCCitation
Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling. 2016, 115 (6):2761-78 J. Neurophysiol.Journal
Journal of neurophysiologyRights
Copyright © 2016 by the American Physiological Society.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
The retina adjusts its signaling gain over a wide range of light levels. A functional result of this is increased visual acuity at brighter luminance levels (light adaptation) due to shifts in the excitatory center-inhibitory surround receptive field parameters of ganglion cells that increases their sensitivity to smaller light stimuli. Recent work supports the idea that changes in ganglion cell spatial sensitivity with background luminance are due in part to inner retinal mechanisms, possibly including modulation of inhibition onto bipolar cells. To determine how the receptive fields of OFF cone bipolar cells may contribute to changes in ganglion cell resolution, the spatial extent and magnitude of inhibitory and excitatory inputs were measured from OFF bipolar cells under dark- and light-adapted conditions. There was no change in the OFF bipolar cell excitatory input with light adaptation; however, the spatial distributions of inhibitory inputs, including both glycinergic and GABAergic sources, became significantly narrower, smaller, and more transient. The magnitude and size of the OFF bipolar cell center-surround receptive fields as well as light-adapted changes in resting membrane potential were incorporated into a spatial model of OFF bipolar cell output to the downstream ganglion cells, which predicted an increase in signal output strength with light adaptation. We show a prominent role for inner retinal spatial signals in modulating the modeled strength of bipolar cell output to potentially play a role in ganglion cell visual sensitivity and acuity.Note
Published 24 February 2016; final publication 1 June 2016. 12 month embargo.ISSN
1522-1598PubMed ID
26912599Version
Final accepted manuscriptAdditional Links
https://jn.physiology.org/content/115/6/2761ae974a485f413a2113503eed53cd6c53
10.1152/jn.00948.2015
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