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    Longitudinal Effects of Embryonic Exposure to Cocaine on Morphology, Cardiovascular Physiology, and Behavior in Zebrafish

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    Author
    Mersereau, Eric
    Boyle, Cody
    Poitra, Shelby
    Espinoza, Ana
    Seiler, Joclyn
    Longie, Robert
    Delvo, Lisa
    Szarkowski, Megan
    Maliske, Joshua
    Chalmers, Sarah
    Darland, Diane
    Darland, Tristan
    Show allShow less
    Affiliation
    Univ Arizona, Dept Ecol & Evolutionary Biol
    Issue Date
    2016-05-31
    Keywords
    cocaine
    zebrafish
    cardiovascular physiology
    behavior
    
    Metadata
    Show full item record
    Publisher
    MDPI AG
    Citation
    Longitudinal Effects of Embryonic Exposure to Cocaine on Morphology, Cardiovascular Physiology, and Behavior in Zebrafish 2016, 17 (6):847 International Journal of Molecular Sciences
    Journal
    International Journal of Molecular Sciences
    Rights
    © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    A sizeable portion of the societal drain from cocaine abuse results from the complications of in utero drug exposure. Because of challenges in using humans and mammalian model organisms as test subjects, much debate remains about the impact of in utero cocaine exposure. Zebrafish offer a number of advantages as a model in longitudinal toxicology studies and are quite sensitive physiologically and behaviorally to cocaine. In this study, we have used zebrafish to model the effects of embryonic pre-exposure to cocaine on development and on subsequent cardiovascular physiology and cocaine-induced conditioned place preference (CPP) in longitudinal adults. Larval fish showed a progressive decrease in telencephalic size with increased doses of cocaine. These treated larvae also showed a dose dependent response in heart rate that persisted 24 h after drug cessation. Embryonic cocaine exposure had little effect on overall health of longitudinal adults, but subtle changes in cardiovascular physiology were seen including decreased sensitivity to isoproterenol and increased sensitivity to cocaine. These longitudinal adult fish also showed an embryonic dose-dependent change in CPP behavior, suggesting an increased sensitivity. These studies clearly show that pre-exposure during embryonic development affects subsequent cocaine sensitivity in longitudinal adults.
    Note
    Open Access Journal
    ISSN
    1422-0067
    DOI
    10.3390/ijms17060847
    Version
    Final published version
    Sponsors
    University of North Dakota (UND); Department of Pathology at the UND School of Medicine and Health Sciences; National Science Foundation (NSF) REU Site [0851869]; National Institutes of Health (NIH) [P20GM103442/P20RR016471]; Indian Health Service (IHS) [U261HS0045-04-01]; NIH
    Additional Links
    http://www.mdpi.com/1422-0067/17/6/847
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms17060847
    Scopus Count
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