Show simple item record

dc.contributor.advisorKhalpey, Zainen
dc.contributor.authorIwanski, Jessika
dc.creatorIwanski, Jessikaen
dc.date.accessioned2016-10-03T18:22:46Z
dc.date.available2016-10-03T18:22:46Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10150/620838
dc.description.abstractTransmyocardial revascularization (TMR) has emerged as an additional therapeutic option for patients suffering from diffuse coronary artery disease (CAD), providing immediate angina relief. The current potential of this therapy focuses on the injection of stem cells, in order to create a synergistic angiogenic effect while increasing myocardial repair and regeneration. Although TMR procedures provide increased vascularization within the myocardium, patients suffering from ischemic cardiomyopathy may not benefit from angiogenesis alone. Therefore, the goal of introducing stem cells is to restore the functional state of a failing heart by providing stem cells with a favorable microenvironment that will enhance their engraftment. Since the therapeutic effect of stem cells is dependent on their capacity to survive and retain in the myocardium, laser therapy may provide a strategy for increasing stem cell engraftment. If so, these cells may have the potential to act as mitochondrial donors or as sources of paracrine factors, aiding in the recovery from oxidative stress and providing antioxidant reserves. Furthermore, laser therapy may also play an influential role in regulating cardiac repair and regeneration via epithelial-mesenchymal transition (EMT). By interacting with specific transcription factors TMR may provide another pathway by which it can offer reparative effects. Cumulatively, paracrine release, denervation, and angiogenesis contribute to the therapeutic benefits experienced by TMR patients, including a significant reduction in angina, with increases in myocardial perfusion and survival rates. With the addition of stem cells, these effects may be further augmented, thus providing increased symptomatic relief in patients.
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.subjectHearten
dc.subjectInfarctionen
dc.subjectLaser Therapyen
dc.subjectStem Cellsen
dc.subjectTMRen
dc.subjectMedical Pharmacologyen
dc.subjectAnginaen
dc.titleTransmyocardial Laser Revascularization and Stem Cell Therapy to Remodel an Infarcted Hearten_US
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.grantorUniversity of Arizonaen
thesis.degree.levelmastersen
dc.contributor.committeememberWong, Raymond K.en
dc.contributor.committeememberRunyan, Raymond B.en
thesis.degree.disciplineGraduate Collegeen
thesis.degree.disciplineMedical Pharmacologyen
thesis.degree.nameM.S.en
refterms.dateFOA2018-09-11T14:57:42Z
html.description.abstractTransmyocardial revascularization (TMR) has emerged as an additional therapeutic option for patients suffering from diffuse coronary artery disease (CAD), providing immediate angina relief. The current potential of this therapy focuses on the injection of stem cells, in order to create a synergistic angiogenic effect while increasing myocardial repair and regeneration. Although TMR procedures provide increased vascularization within the myocardium, patients suffering from ischemic cardiomyopathy may not benefit from angiogenesis alone. Therefore, the goal of introducing stem cells is to restore the functional state of a failing heart by providing stem cells with a favorable microenvironment that will enhance their engraftment. Since the therapeutic effect of stem cells is dependent on their capacity to survive and retain in the myocardium, laser therapy may provide a strategy for increasing stem cell engraftment. If so, these cells may have the potential to act as mitochondrial donors or as sources of paracrine factors, aiding in the recovery from oxidative stress and providing antioxidant reserves. Furthermore, laser therapy may also play an influential role in regulating cardiac repair and regeneration via epithelial-mesenchymal transition (EMT). By interacting with specific transcription factors TMR may provide another pathway by which it can offer reparative effects. Cumulatively, paracrine release, denervation, and angiogenesis contribute to the therapeutic benefits experienced by TMR patients, including a significant reduction in angina, with increases in myocardial perfusion and survival rates. With the addition of stem cells, these effects may be further augmented, thus providing increased symptomatic relief in patients.


Files in this item

Thumbnail
Name:
azu_etd_14766_sip1_m.pdf
Size:
2.728Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record