Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic.
Harris, Robin B
O'Rourke, Mary Kay
Burgess, Jefferey L
AffiliationUniversity of Arizona College of Medicine and Public Health
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationRelation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic. 2016, 26 (5):445-51 J Expo Sci Environ Epidemiol
Rights© 2016 Nature America, Inc. All rights reserved.
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AbstractArsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Our objective was to evaluate the effects of dietary components of inorganic As (iAs) intake on serum MMP-9 concentration at differing levels of tap water As. In a cross-sectional study of 214 adults, dietary iAs intake was estimated from 24-h dietary recall interviews using published iAs residue data; drinking and cooking water As intake from water samples and consumption data. Aggregate iAs intake (food plus water) was associated with elevated serum MMP-9 in mixed model regression, with and without adjustment for covariates. In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As≤10 μg/l. Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As≤3 μg/l. Exposure to iAs from food and water combined, in areas where tap water As concentration is ≤10 μg/l, may contribute to As-induced changes in a biomarker associated with toxicity.
NotePublished online 21 January 2015; 6 month embargo.
VersionFinal accepted manuscript
SponsorsU.S. EPA Star Grant # R83399201-0; University of Arizona Specialized Program of Research Excellence (SPORE) (NIH/NCI Grant # CA95060); Southwest Environmental Health Sciences Center (NIEHS Grant # ES06694)