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dc.contributor.authorKurzius-Spencer, Margaret
dc.contributor.authorHarris, Robin B
dc.contributor.authorHartz, Vern
dc.contributor.authorRoberge, Jason
dc.contributor.authorHsu, Chiu-Hsieh
dc.contributor.authorO'Rourke, Mary Kay
dc.contributor.authorBurgess, Jefferey L
dc.date.accessioned2016-10-12T01:10:33Z
dc.date.available2016-10-12T01:10:33Z
dc.date.issued2016-10
dc.identifier.citationRelation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic. 2016, 26 (5):445-51 J Expo Sci Environ Epidemiolen
dc.identifier.issn1559-064X
dc.identifier.pmid25605447
dc.identifier.doi10.1038/jes.2014.92
dc.identifier.urihttp://hdl.handle.net/10150/620929
dc.description.abstractArsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Our objective was to evaluate the effects of dietary components of inorganic As (iAs) intake on serum MMP-9 concentration at differing levels of tap water As. In a cross-sectional study of 214 adults, dietary iAs intake was estimated from 24-h dietary recall interviews using published iAs residue data; drinking and cooking water As intake from water samples and consumption data. Aggregate iAs intake (food plus water) was associated with elevated serum MMP-9 in mixed model regression, with and without adjustment for covariates. In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As≤10 μg/l. Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As≤3 μg/l. Exposure to iAs from food and water combined, in areas where tap water As concentration is ≤10 μg/l, may contribute to As-induced changes in a biomarker associated with toxicity.
dc.description.sponsorshipU.S. EPA Star Grant # R83399201-0; University of Arizona Specialized Program of Research Excellence (SPORE) (NIH/NCI Grant # CA95060); Southwest Environmental Health Sciences Center (NIEHS Grant # ES06694)en
dc.language.isoenen
dc.publisherNATURE PUBLISHING GROUPen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698357/pdf/nihms746565.pdfen
dc.rights© 2016 Nature America, Inc. All rights reserved.en
dc.subjectarsenicen
dc.subjectMMP-9en
dc.subjectdietary exposureen
dc.subjectbiomarker of toxicityen
dc.titleRelation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic.en
dc.typeArticleen
dc.contributor.departmentUniversity of Arizona College of Medicine and Public Healthen
dc.identifier.journalJournal of exposure science & environmental epidemiologyen
dc.description.notePublished online 21 January 2015; 6 month embargo.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal accepted manuscripten
refterms.dateFOA2018-08-13T19:24:53Z
html.description.abstractArsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Our objective was to evaluate the effects of dietary components of inorganic As (iAs) intake on serum MMP-9 concentration at differing levels of tap water As. In a cross-sectional study of 214 adults, dietary iAs intake was estimated from 24-h dietary recall interviews using published iAs residue data; drinking and cooking water As intake from water samples and consumption data. Aggregate iAs intake (food plus water) was associated with elevated serum MMP-9 in mixed model regression, with and without adjustment for covariates. In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As≤10 μg/l. Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As≤3 μg/l. Exposure to iAs from food and water combined, in areas where tap water As concentration is ≤10 μg/l, may contribute to As-induced changes in a biomarker associated with toxicity.


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