Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.
Final Accepted Manuscript
Clarke, John D
Dzierlenga, Anika L
Klein, David M
Cherrington, Nathan J
AffiliationUniv Arizona, Dept Pharmacol & Toxicol
MetadataShow full item record
PublisherPERGAMON-ELSEVIER SCIENCE LTD
CitationEffect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir. 2016, 115:144-51 Biochem. Pharmacol.
Rights© 2016 Elsevier Inc. All rights reserved.
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AbstractAdefovir, an acyclic nucleotide reverse transcriptase inhibitor used to treat hepatitis B viral infection, is primarily eliminated renally through cooperation of glomerular filtration with active tubular transport. Nonalcoholic steatohepatitis is a variable in drug disposition, yet the impact on renal transport processes has yet to be fully understood. The goal of this study was to determine the effect of nonalcoholic steatohepatitis on the pharmacokinetics of adefovir in rats given a control or methionine and choline deficient diet to induce nonalcoholic steatohepatitis.
NoteAvailable online 2 July 2016. 12 month embargo.
VersionFinal accepted manuscript
SponsorsEuropean Social Fund; state budget of the Czech Republic [CZ.1.07/2.3.00/30.006]; National Institutes of Health (USA) [HD062489, DK068039]