Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.
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Laho_AdefovirInNASH_Final.pdf
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Final Accepted Manuscript
Author
Laho, TomasClarke, John D
Dzierlenga, Anika L
Li, Hui
Klein, David M
Goedken, Michael
Micuda, Stanislav
Cherrington, Nathan J
Affiliation
Univ Arizona, Dept Pharmacol & ToxicolIssue Date
2016-09-01
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PERGAMON-ELSEVIER SCIENCE LTDCitation
Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir. 2016, 115:144-51 Biochem. Pharmacol.Journal
Biochemical pharmacologyRights
© 2016 Elsevier Inc. All rights reserved.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Adefovir, an acyclic nucleotide reverse transcriptase inhibitor used to treat hepatitis B viral infection, is primarily eliminated renally through cooperation of glomerular filtration with active tubular transport. Nonalcoholic steatohepatitis is a variable in drug disposition, yet the impact on renal transport processes has yet to be fully understood. The goal of this study was to determine the effect of nonalcoholic steatohepatitis on the pharmacokinetics of adefovir in rats given a control or methionine and choline deficient diet to induce nonalcoholic steatohepatitis.Note
Available online 2 July 2016. 12 month embargo.ISSN
1873-2968PubMed ID
27381944Version
Final accepted manuscriptSponsors
European Social Fund; state budget of the Czech Republic [CZ.1.07/2.3.00/30.006]; National Institutes of Health (USA) [HD062489, DK068039]ae974a485f413a2113503eed53cd6c53
10.1016/j.bcp.2016.07.001