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    Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir

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    Author
    Laho, Tomas
    Clarke, John D
    Dzierlenga, Anika L
    Li, Hui
    Klein, David M
    Goedken, Michael
    Micuda, Stanislav
    Cherrington, Nathan J
    Affiliation
    Univ Arizona, Dept Pharmacol & Toxicol
    Issue Date
    2016-09-01
    Keywords
    Adefovir
    GFR
    NASH
    Renal elimination
    
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    Show full item record
    Publisher
    PERGAMON-ELSEVIER SCIENCE LTD
    Citation
    Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir. 2016, 115:144-51 Biochem. Pharmacol.
    Journal
    Biochemical pharmacology
    Rights
    © 2016 Elsevier Inc. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Adefovir, an acyclic nucleotide reverse transcriptase inhibitor used to treat hepatitis B viral infection, is primarily eliminated renally through cooperation of glomerular filtration with active tubular transport. Nonalcoholic steatohepatitis is a variable in drug disposition, yet the impact on renal transport processes has yet to be fully understood. The goal of this study was to determine the effect of nonalcoholic steatohepatitis on the pharmacokinetics of adefovir in rats given a control or methionine and choline deficient diet to induce nonalcoholic steatohepatitis.
    Note
    Available online 2 July 2016. 12 month embargo.
    ISSN
    1873-2968
    PubMed ID
    27381944
    DOI
    10.1016/j.bcp.2016.07.001
    Version
    Final accepted manuscript
    Sponsors
    European Social Fund; state budget of the Czech Republic [CZ.1.07/2.3.00/30.006]; National Institutes of Health (USA) [HD062489, DK068039]
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bcp.2016.07.001
    Scopus Count
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