Continued Risk of Relapse Independent of Treatment Modality in Limited-Stage Diffuse Large B-Cell Lymphoma: Final and Long-Term Analysis of Southwest Oncology Group Study S8736.
AuthorStephens, Deborah M
LeBlanc, Michael L
Puvvada, Soham D
Friedberg, Jonathan W
Smith, Sonali M
MetadataShow full item record
PublisherAMER SOC CLINICAL ONCOLOGY
CitationContinued Risk of Relapse Independent of Treatment Modality in Limited-Stage Diffuse Large B-Cell Lymphoma: Final and Long-Term Analysis of Southwest Oncology Group Study S8736. 2016, 34 (25):2997-3004 J. Clin. Oncol.
JournalJournal of clinical oncology : official journal of the American Society of Clinical Oncology
RightsCopyright © 2016, American Society of Clinical Oncology.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractUtility of combined-modality therapy for patients with limited-stage diffuse large B-cell lymphoma (DLBCL) was shown in the Southwest Oncology Group (SWOG) S8736 study, where three cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) plus radiotherapy (CHOP3RT) improved 5-year progression-free (PFS) and overall survival (OS) compared with eight cycles of CHOP (CHOP8). Subsequent analysis showed an unexpected overlap of the PFS curves. We aimed to confirm and investigate this observation by performing long-term analysis of SWOG S8736 and evaluating these data alongside data from similar patients receiving rituximab and CHOP3RT (SWOG S0014 study).
NotePublished online ahead of print at www.jco.org on July 5, 2016. 12 month embargo.
VersionFinal published version
SponsorsNational Institutes of Health (NIH)/National Cancer Institute (NCI)/National Clinical Trials Network [CA180888, CA180819, CA180801, CA 180834, CA 180846, CA180835, CA180818, CA180830, CA180828]; NIH/NCI Community Oncology Research Program Grants [CA189953, CA189952, CA189954, CA189808, CA189830, CA189957, CA189822, CA189853, CA189860]
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