Continued Risk of Relapse Independent of Treatment Modality in Limited-Stage Diffuse Large B-Cell Lymphoma: Final and Long-Term Analysis of Southwest Oncology Group Study S8736.
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JCO-2016-Stephens-JCO.2015.65. ...
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Stephens, Deborah MLi, Hongli
LeBlanc, Michael L
Puvvada, Soham D
Persky, Daniel
Friedberg, Jonathan W
Smith, Sonali M
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Univ ArizonaIssue Date
2016-09-01
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AMER SOC CLINICAL ONCOLOGYCitation
Continued Risk of Relapse Independent of Treatment Modality in Limited-Stage Diffuse Large B-Cell Lymphoma: Final and Long-Term Analysis of Southwest Oncology Group Study S8736. 2016, 34 (25):2997-3004 J. Clin. Oncol.Journal
Journal of clinical oncology : official journal of the American Society of Clinical OncologyRights
Copyright © 2016, American Society of Clinical Oncology.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Utility of combined-modality therapy for patients with limited-stage diffuse large B-cell lymphoma (DLBCL) was shown in the Southwest Oncology Group (SWOG) S8736 study, where three cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) plus radiotherapy (CHOP3RT) improved 5-year progression-free (PFS) and overall survival (OS) compared with eight cycles of CHOP (CHOP8). Subsequent analysis showed an unexpected overlap of the PFS curves. We aimed to confirm and investigate this observation by performing long-term analysis of SWOG S8736 and evaluating these data alongside data from similar patients receiving rituximab and CHOP3RT (SWOG S0014 study).Note
Published online ahead of print at www.jco.org on July 5, 2016. 12 month embargo.ISSN
1527-7755PubMed ID
27382104Version
Final published versionSponsors
National Institutes of Health (NIH)/National Cancer Institute (NCI)/National Clinical Trials Network [CA180888, CA180819, CA180801, CA 180834, CA 180846, CA180835, CA180818, CA180830, CA180828]; NIH/NCI Community Oncology Research Program Grants [CA189953, CA189952, CA189954, CA189808, CA189830, CA189957, CA189822, CA189853, CA189860]ae974a485f413a2113503eed53cd6c53
10.1200/JCO.2015.65.4582
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