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dc.contributor.authorTaverna, Josephine*
dc.contributor.authorNair, Anju*
dc.contributor.authorYun, Seongseok*
dc.contributor.authorPaulson, Spencer*
dc.contributor.authorSchatz, Jonathan H.*
dc.contributor.authorPersky, Daniel*
dc.contributor.authorFuchs, Deborah*
dc.contributor.authorPuvvada, Soham*
dc.date.accessioned2016-11-10T05:17:30Z
dc.date.available2016-11-10T05:17:30Z
dc.date.issued2014
dc.identifier.citationA Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature 2014, 2014:1 Case Reports in Hematologyen
dc.identifier.issn2090-6560
dc.identifier.issn2090-6579
dc.identifier.doi10.1155/2014/145129
dc.identifier.urihttp://hdl.handle.net/10150/621342
dc.descriptionUA Open Access Publishing Funden
dc.description.abstractA 65-year-old gentleman presented with left groin swelling over the course of two months. Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions. An excisional lymph node biopsy was performed. Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells. These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL) with in situ mantle cell lymphoma (MCLIS). FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown. This case illustrates the diagnostic and therapeutic challenges of composite lymphomas. This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.
dc.language.isoenen
dc.publisherHindawien
dc.relation.urlhttp://www.hindawi.com/journals/crihem/2014/145129/en
dc.rightsCopyright © 2014 Josephine Taverna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleA Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literatureen
dc.typeArticleen
dc.contributor.departmentDivision of Hematology and Oncology, Department of Medicine, University of Arizona Cancer Center, University of Arizonaen
dc.contributor.departmentDepartment of Medicine, University of Arizonaen
dc.contributor.departmentDepartment of Pathology, University of Arizonaen
dc.identifier.journalCase Reports in Hematologyen
dc.description.noteOpen access journalen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
refterms.dateFOA2018-08-13T19:29:18Z
html.description.abstractA 65-year-old gentleman presented with left groin swelling over the course of two months. Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions. An excisional lymph node biopsy was performed. Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells. These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL) with in situ mantle cell lymphoma (MCLIS). FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown. This case illustrates the diagnostic and therapeutic challenges of composite lymphomas. This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.


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