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    Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs

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    Author
    Shubitz, Lisa
    Roy, Michael E
    Nix, David
    Galgiani, John N.
    Affiliation
    The University of Arizona
    Issue Date
    2013-10
    Keywords
    Coccidioidomycosis
    Coccidioides immitis
    Coccidioides posadasii
    canine
    Dogs.
    Nikkomycin Z
    medication
    
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    Rights
    Copyright © Arizona Board of Regents.
    Collection Information
    This data is made available by the Valley Fever Center for Excellence and the University of Arizona Libraries. Questions or permission for re-use of content should be addressed to Lisa Shubitz, DVM at lfshubit@email.arizona.edu or 520-626-8198.
    Description
    Nikkomycin Z (NikZ) is a chitin synthase inhibitor with antifungal efficacy against Coccidioides spp. and other endemic fungi. Dogs suffer a rate and range of natural coccidioidomycosis similar to humans and were considered an excellent model for initially testing NikZ against naturally acquired disease. Twelve dogs with coccidioidal pneumonia that had been present for an average of three months were treated with 250 mg (5 - 15 kg) or 500 mg (> 15 - 30 kg) twice daily for 60 days. Nine dogs completed the course of treatment and seven dogs had improvement in disease based on radiographs, clinicopathological parameters, physical examination findings, and subjective assessment by the owners; three dogs had resolution or near resolution of disease. Based on this small study, NikZ shows efficacy to treat naturally acquired coccidioidomycosis and merits further development for trials in humans.
    Note
    The datasets are divided into 6 groups. The data for the nine dogs that completed the study are shown in: Signalment, Enrollment Visit, Midpoint Visit, Pharmacokinetic Data, and End Visit. The information for the three dogs that did not complete the study is presented in Withdrawn Dogs. The results of the analysis were published: Shubitz, LF, Roy, ME, Nix, DE, et al. (2013). Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs. Medical Mycology, 51, 747-754.
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