Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs

Shubitz, Lisa; Roy, Michael E; Nix, David; Galgiani, John N.

dc.contributor.author	Shubitz, Lisa
dc.contributor.author	Roy, Michael E
dc.contributor.author	Nix, David
dc.contributor.author	Galgiani, John N.
dc.date.accessioned	2016-11-30T16:45:33Z
dc.date.available	2016-11-30T16:45:33Z
dc.date.issued	2013-10
dc.identifier.uri	http://hdl.handle.net/10150/621447
dc.description	Nikkomycin Z (NikZ) is a chitin synthase inhibitor with antifungal efficacy against Coccidioides spp. and other endemic fungi. Dogs suffer a rate and range of natural coccidioidomycosis similar to humans and were considered an excellent model for initially testing NikZ against naturally acquired disease. Twelve dogs with coccidioidal pneumonia that had been present for an average of three months were treated with 250 mg (5 - 15 kg) or 500 mg (> 15 - 30 kg) twice daily for 60 days. Nine dogs completed the course of treatment and seven dogs had improvement in disease based on radiographs, clinicopathological parameters, physical examination findings, and subjective assessment by the owners; three dogs had resolution or near resolution of disease. Based on this small study, NikZ shows efficacy to treat naturally acquired coccidioidomycosis and merits further development for trials in humans.	en
dc.language.iso	en_US	en
dc.rights	Copyright © Arizona Board of Regents.	en
dc.subject	Coccidioidomycosis	en
dc.subject	Coccidioides immitis	en
dc.subject	Coccidioides posadasii	en
dc.subject	canine	en
dc.subject	Dogs.	en
dc.subject	Nikkomycin Z	en
dc.subject	medication	en
dc.title	Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs	en_US
dc.title.alternative	Data collection	en
dc.type	Dataset	en
dc.contributor.department	The University of Arizona	en
dc.description.note	The datasets are divided into 6 groups. The data for the nine dogs that completed the study are shown in: Signalment, Enrollment Visit, Midpoint Visit, Pharmacokinetic Data, and End Visit. The information for the three dogs that did not complete the study is presented in Withdrawn Dogs. The results of the analysis were published: Shubitz, LF, Roy, ME, Nix, DE, et al. (2013). Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs. Medical Mycology, 51, 747-754.	en
dc.description.collectioninformation	This data is made available by the Valley Fever Center for Excellence and the University of Arizona Libraries. Questions or permission for re-use of content should be addressed to Lisa Shubitz, DVM at lfshubit@email.arizona.edu or 520-626-8198.	en
refterms.dateFOA	2018-04-20T04:26:13Z