Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes
Author
Powers, AbigailMichopoulos, Vasiliki
Conneely, Karen
Gluck, Rachel
Dixon, Hayley

Wilson, Joseph
Jovanovic, Tanja
Pace, Thaddeus W. W.
Umpierrez, Guillermo E.
Ressler, Kerry J.
Bradley, Bekh
Gillespie, Charles F.

Affiliation
Univ Arizona, Coll NursingUniv Arizona, Coll Med Psychiat
Issue Date
2016
Metadata
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HINDAWI PUBLISHING CORPCitation
Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes 2016, 2016:1 Neural PlasticityJournal
Neural PlasticityRights
Copyright © 2016 Abigail Powers et al. This is an open access article distributed under the Creative Commons Attribution License.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
C-reactive protein (CRP), a marker of systemic inflammation, has been associated with major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Emotion dysregulation is a transdiagnostic risk factor for many psychological disorders associated with chronic inflammatory state. The objective of this study was to determine whether inflammation is associated with emotion dysregulation in women with type 2 diabetes mellitus (T2DM). We examined associations between trauma exposure, MDD, PTSD, emotion dysregulation, and CRP among 40 African-American women with T2DM recruited from an urban hospital. Emotion dysregulation was measured using the Difficulties in Emotion Regulation Scale. PTSD and MDD were measured with structured clinical interviews. Child abuse and lifetime trauma load were also assessed. Analyses showed that both emotion dysregulation and current MDD were significantly associated with higher levels of CRP ( p < 0.01 ). Current PTSD was not significantly related to CRP. In a regression model, emotion dysregulation was significantly associated with higher CRP ( p < 0.001 ) independent of body mass index, trauma exposure, and MDD diagnosis. These findings suggest that emotion dysregulation may be an important risk factor for chronic inflammation beyond already known risk factors among women with T2DM, though a causal relationship cannot be determined from this study.ISSN
2090-59041687-5443
Version
Final published versionSponsors
National Institute of Mental Health [MH071537, MH102890, MH099211]; National Institute of Child Health and Human Development [HD071982]; Emory and Grady Memorial Hospital General Clinical Research Center, NIH National Centers for Research Resources [M01 RR00039]Additional Links
http://www.hindawi.com/journals/np/2016/8926840/ae974a485f413a2113503eed53cd6c53
10.1155/2016/8926840
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Except where otherwise noted, this item's license is described as Copyright © 2016 Abigail Powers et al. This is an open access article distributed under the Creative Commons Attribution License.