Fentanyl sublingual spray for breakthrough cancer pain in patients receiving transdermal fentanyl
Publisher
FUTURE MEDICINE LTDCitation
Fentanyl sublingual spray for breakthrough cancer pain in patients receiving transdermal fentanyl 2016, 6 (5):427 Pain ManagementJournal
Pain ManagementRights
Copyright © David S Alberts, MD, & co-authors. This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Aim: To investigate the relationship between effective fentanyl sublingual spray (FSS) doses for breakthrough cancer pain (BTCP) and around-the-clock (ATC) transdermal fentanyl patch (TFP). Methods: Adults tolerating ATC opioids received open-label FSS for 26 days, followed by a 26-day double-blind phase for patients achieving an effective dose (100-1600 mu g). Results: Out of 50 patients on ATC TFP at baseline, 32 (64%) achieved an effective dose. FSS effective dose moderately correlated with mean TFP dose (r = 0.4; p = 0.03). Patient satisfaction increased during the study. Common adverse events included nausea (9%) and peripheral edema (9%). Conclusion: FSS can be safely titrated to an effective dose for BTCP in patients receiving ATC TFP as chronic cancer pain medication. ClinicalTrials.gov identifier: NCT00538850Note
Authors chose open access article option (hybrid journal).ISSN
1758-18691758-1877
Version
Final published versionAdditional Links
http://www.futuremedicine.com/doi/10.2217/pmt-2015-0009ae974a485f413a2113503eed53cd6c53
10.2217/pmt-2015-0009
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Except where otherwise noted, this item's license is described as Copyright © David S Alberts, MD, & co-authors. This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.