DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses
Mayer, Klaus F. X.
Marri, Pradeep Reddy
Wing, Rod A.
AffiliationUniv Arizona, Arizona Genom Inst, Sch Plant Sci
Univ Arizona, Dept Ecol & Evolutionary Biol
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationDNA transposon activity is associated with increased mutation rates in genes of rice and other grasses 2016, 7:12790 Nature Communications
Rights© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License.
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AbstractDNA (class 2) transposons are mobile genetic elements which move within their 'host' genome through excising and re-inserting elsewhere. Although the rice genome contains tens of thousands of such elements, their actual role in evolution is still unclear. Analysing over 650 transposon polymorphisms in the rice species Oryza sativa and Oryza glaberrima, we find that DNA repair following transposon excisions is associated with an increased number of mutations in the sequences neighbouring the transposon. Indeed, the 3,000 bp flanking the excised transposons can contain over 10 times more mutations than the genome-wide average. Since DNA transposons preferably insert near genes, this is correlated with increases in mutation rates in coding sequences and regulatory regions. Most importantly, we find this phenomenon also in maize, wheat and barley. Thus, these findings suggest that DNA transposon activity is a major evolutionary force in grasses which provide the basis of most food consumed by humankind.
VersionFinal published version
SponsorsSwiss National Foundation [31003A_138505/1]; US National Science Foundation [0321678, 0638541, 0822284, 1026200]; Bud Antle Endowed Chair of Excellence in Agriculture and Life Sciences; AXA Endowed Chair of Genome Biology and Evolutionary Genomics