Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism
Forsythe, Evan S.
Beilstein, Mark A.
AffiliationUniv Arizona, Sch Plant Sci
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationEvolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism 2016, 7:13026 Nature Communications
Rights© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License.
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AbstractExpansion of the cytochrome P450 gene family is often proposed to have a critical role in the evolution of metabolic complexity, in particular in microorganisms, insects and plants. However, the molecular mechanisms underlying the evolution of this complexity are poorly understood. Here we describe the evolutionary history of a plant P450 retrogene, which emerged and underwent fixation in the common ancestor of Brassicales, before undergoing tandem duplication in the ancestor of Brassicaceae. Duplication leads first to gain of dual functions in one of the copies. Both sister genes are retained through subsequent speciation but eventually return to a single copy in two of three diverging lineages. In the lineage in which both copies are maintained, the ancestral functions are split between paralogs and a novel function arises in the copy under relaxed selection. Our work illustrates how retrotransposition and gene duplication can favour the emergence of novel metabolic functions.
VersionFinal published version
SponsorsChina Scholarship Council; Region Alsace; Agence Nationale pour la Recherche [ANR-10-BLAN-1528]; Freiburg Institute for Advanced Studies (FRIAS); University of Strasbourg Institute for Advanced Study (USIAS); National Science Foundation of the United States [MCB 1409251]