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dc.contributor.authorGan, Xiangchao
dc.contributor.authorHay, Angela
dc.contributor.authorKwantes, Michiel
dc.contributor.authorHaberer, Georg
dc.contributor.authorHallab, Asis
dc.contributor.authorIoio, Raffaele Dello
dc.contributor.authorHofhuis, Hugo
dc.contributor.authorPieper, Bjorn
dc.contributor.authorCartolano, Maria
dc.contributor.authorNeumann, Ulla
dc.contributor.authorNikolov, Lachezar A.
dc.contributor.authorSong, Baoxing
dc.contributor.authorHajheidari, Mohsen
dc.contributor.authorBriskine, Roman
dc.contributor.authorKougioumoutzi, Evangelia
dc.contributor.authorVlad, Daniela
dc.contributor.authorBroholm, Suvi
dc.contributor.authorHein, Jotun
dc.contributor.authorMeksem, Khalid
dc.contributor.authorLightfoot, David
dc.contributor.authorShimizu, Kentaro K.
dc.contributor.authorShimizu-Inatsugi, Rie
dc.contributor.authorImprialou, Martha
dc.contributor.authorKudrna, David
dc.contributor.authorWing, Rod
dc.contributor.authorSato, Shusei
dc.contributor.authorHuijser, Peter
dc.contributor.authorFilatov, Dmitry
dc.contributor.authorMayer, Klaus F. X.
dc.contributor.authorMott, Richard
dc.contributor.authorTsiantis, Miltos
dc.date.accessioned2017-01-13T22:11:47Z
dc.date.available2017-01-13T22:11:47Z
dc.date.issued2016-10-31
dc.identifier.citationThe Cardamine hirsuta genome offers insight into the evolution of morphological diversity 2016, 2 (11):16167 Nature Plantsen
dc.identifier.issn2055-0278
dc.identifier.doi10.1038/nplants.2016.167
dc.identifier.urihttp://hdl.handle.net/10150/621979
dc.description.abstractFinding causal relationships between genotypic and phenotypic variation is a key focus of evolutionary biology, human genetics and plant breeding. To identify genome-wide patterns underlying trait diversity, we assembled a high-quality reference genome of Cardamine hirsuta, a close relative of the model plant Arabidopsis thaliana. We combined comparative genome and transcriptome analyses with the experimental tools available in C. hirsuta to investigate gene function and phenotypic diversification. Our findings highlight the prevalent role of transcription factors and tandem gene duplications in morphological evolution. We identified a specific role for the transcriptional regulators PLETHORA5/7 in shaping leaf diversity and link tandem gene duplication with differential gene expression in the explosive seed pod of C. hirsuta. Our work highlights the value of comparative approaches in genetically tractable species to understand the genetic basis for evolutionary change.
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council [BB/H011455/1, BB/H01313X/1]; Gatsby Charitable foundation grant; Deutsche Forschungsgemeinschaft priority programme 'Adaptomics' grant [TS 229/1-1, HA 6316/1-3]; University of Oxford pump-priming grant; Human Frontiers Science Programme Young Investigators grant [RGY0087/2011]; EU Cofund Plant Fellow; URPP Evolution in Action; MEXT KAKENHI [16H06469]; Swiss National Science Foundation; Max Planck Society W2en
dc.language.isoenen
dc.publisherNATURE PUBLISHING GROUPen
dc.relation.urlhttp://www.nature.com/articles/nplants2016167en
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.titleThe Cardamine hirsuta genome offers insight into the evolution of morphological diversityen
dc.typeArticleen
dc.identifier.journalNature Plantsen
dc.description.noteOpen access article.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
refterms.dateFOA2018-06-29T04:01:08Z
html.description.abstractFinding causal relationships between genotypic and phenotypic variation is a key focus of evolutionary biology, human genetics and plant breeding. To identify genome-wide patterns underlying trait diversity, we assembled a high-quality reference genome of Cardamine hirsuta, a close relative of the model plant Arabidopsis thaliana. We combined comparative genome and transcriptome analyses with the experimental tools available in C. hirsuta to investigate gene function and phenotypic diversification. Our findings highlight the prevalent role of transcription factors and tandem gene duplications in morphological evolution. We identified a specific role for the transcriptional regulators PLETHORA5/7 in shaping leaf diversity and link tandem gene duplication with differential gene expression in the explosive seed pod of C. hirsuta. Our work highlights the value of comparative approaches in genetically tractable species to understand the genetic basis for evolutionary change.


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