Synergism and Antagonism of Proximate Mechanisms Enable and Constrain the Response to Simultaneous Selection on Body Size and Development Time: An Empirical Test Using Experimental Evolution
AffiliationUniv Arizona, Dept Ecol & Evolutionary Biol
Univ Arizona, Dept Entomol
MetadataShow full item record
PublisherUNIV CHICAGO PRESS
CitationSynergism and Antagonism of Proximate Mechanisms Enable and Constrain the Response to Simultaneous Selection on Body Size and Development Time: An Empirical Test Using Experimental Evolution 2016, 188 (5):499 The American Naturalist
JournalThe American Naturalist
Rights© 2016 by The University of Chicago. All rights reserved. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractNatural selection acts on multiple traits simultaneously. How mechanisms underlying such traits enable or constrain their response to simultaneous selection is poorly understood. We show how antagonism and synergism among three traits at the developmental level enable or constrain evolutionary change in response to simultaneous selection on two focal traits at the phenotypic level. After 10 generations of 25% simultaneous directional selection on all four combinations of body size and development time in Manduca sexta (Sphingidae), the changes in the three developmental traits predict 93% of the response of development time and 100% of the response of body size. When the two focal traits were under synergistic selection, the response to simultaneous selection was enabled by juvenile hormone and ecdysteroids and constrained by growth rate. When the two focal traits were under antagonistic selection, the response to selection was due primarily to change in growth rate and constrained by the two hormonal traits. The approach used here reduces the complexity of the developmental and endocrine mechanisms to three proxy traits. This generates explicit predictions for the evolutionary response to selection that are based on biologically informed mechanisms. This approach has broad applicability to a diverse range of taxa, including algae, plants, amphibians, mammals, and insects.
NoteONLINE: Sept 20, 2016; 12 Month Embargo.
VersionFinal published version
SponsorsNational Science Foundation (NSF), USA [IBN-0212621]; NSF [IOS-1053318, IOS-1121065]
- Endocrine Proxies Can Simplify Endocrine Complexity to Enable Evolutionary Prediction.
- Authors: Davidowitz G
- Issue date: 2016 Aug
- Conflicting processes in the evolution of body size and development time.
- Authors: Nijhout HF, Roff DA, Davidowitz G
- Issue date: 2010 Feb 27
- A physiological perspective on the response of body size and development time to simultaneous directional selection.
- Authors: Davidowitz G, Roff DA, Nijhout HF
- Issue date: 2005 Jun
- Predicting the response to simultaneous selection: genetic architecture and physiological constraints.
- Authors: Davidowitz G, Nijhout HF, Roff DA
- Issue date: 2012 Sep
- An integrated analysis of phenotypic selection on insect body size and development time.
- Authors: Eck DJ, Shaw RG, Geyer CJ, Kingsolver JG
- Issue date: 2015 Sep