Serum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse?
AffiliationUniv Arizona, Div Infect Dis
Univ Arizona, Dept Pathol
MetadataShow full item record
PublisherOXFORD UNIV PRESS INC
CitationSerum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse? 2016, 3 (3):ofw166 Open Forum Infectious Diseases
JournalOpen Forum Infectious Diseases
Rights© The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractIt is a striking observation that tissue of patients invaded by the deep mycoses often lacks evidence of an inflammatory response. This lack of host response is often attributed to neutropenia secondary to chemotherapy. However, systematic studies do not support this simplistic explanation. However, invasive fungal lesions are characterized by abundant fungal functional amyloid, which in turn is bound by serum amyloid P component (SAP). We postulate that SAP is important in the local immune response in invasive fungal infections. The interaction between fungal functional amyloid, SAP, and the immune response in deep mycoses is discussed.
NoteOpen Access Journal.
VersionFinal published version