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    Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression

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    Author
    Mertens, Christina
    Akam, Eman Abureida
    Rehwald, Claudia
    Brüne, Bernhard
    Tomat, Elisa
    Jung, Michaela cc
    Affiliation
    Univ Arizona, Dept Chem & Biochem
    Issue Date
    2016-11-02
    
    Metadata
    Show full item record
    Publisher
    PUBLIC LIBRARY SCIENCE
    Citation
    Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression 2016, 11 (11):e0166164 PLOS ONE
    Journal
    PLOS ONE
    Rights
    © 2016 Mertens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    A growing body of evidence suggests that macrophage polarization dictates the expression of iron-regulated genes. Polarization towards iron sequestration depletes the microenvironment, whereby extracellular pathogen growth is limited and inflammation is fostered. In contrast, iron release contributes to cell proliferation, which is important for tissue regeneration. Moreover, macrophages constitute a major component of the infiltrates in most solid tumors. Considering the pivotal role of macrophages for iron homeostasis and their presence in association with poor clinical prognosis in tumors, we approached the possibility to target macrophages with intracellular iron chelators. Analyzing the expression of iron-regulated genes at mRNA and protein level in primary human macrophages, we found that the iron-release phenotype is a characteristic of polarized macrophages that, in turn, stimulate tumor cell growth and progression. The application of the intracellular iron chelator (TC3-S)(2) shifted the macrophage phenotype from iron release towards sequestration, as determined by the iron-gene profile and atomic absorption spectroscopy (AAS). Moreover, whereas the addition of macrophage supernatants to tumor cells induced tumor growth and metastatic behavior, the supernatant of chelator-treated macrophages reversed this effect. Iron chelators demonstrated potent anti-neoplastic properties in a number of cancers, both in cell culture and in clinical trials. Our results suggest that iron chelation could affect not only cancer cells but also the tumor microenvironment by altering the iron-release phenotype of tumor-associated macrophages (TAMs). The study of iron chelators in conjunction with the effect of TAMs on tumor growth could lead to an improved understanding of the role of iron in cancer biology and to novel therapeutic avenues for iron chelation approaches.
    Note
    Open Access Journal.
    ISSN
    1932-6203
    PubMed ID
    27806101
    DOI
    10.1371/journal.pone.0166164
    Version
    Final published version
    Sponsors
    Fritz Thyssen Stiftung [Az.10.12.2.156]; Goethe-University Frankfurt; Doktor Robert Pfleger Stiftung; University of Arizona Office of Research and Development; University of Arizona Global Initiatives; Deutsche Krebshilfe [111578]
    Additional Links
    http://dx.plos.org/10.1371/journal.pone.0166164
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0166164
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    UA Faculty Publications

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