Body mass and cognitive decline are indirectly associated via inflammation among aging adults
AffiliationDepartment of Psychology, University of Arizona
MetadataShow full item record
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
CitationBody mass and cognitive decline are indirectly associated via inflammation among aging adults 2017, 60:63 Brain, Behavior, and Immunity
JournalBrain, Behavior, and Immunity
Rights© 2016 Elsevier Inc. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractInflammatory models of neurodegeneration suggest that higher circulating levels of inflammation can lead to cognitive decline. Despite established independent associations between greater body mass, increased inflammation, and cognitive decline, no prior research has explored whether markers of systemic inflammation might mediate the association between body mass and changes in cognitive functioning. To test such a model, we used two longitudinal subsamples (ns = 9066; 12,561) of aging adults from the English Longitudinal Study of Ageing (ELSA) study, which included two cognitive measures components of memory and executive functioning, as well as measurements of body mass and systemic inflammation, assessed via C-reactive protein (CRP). Greater body mass was indirectly associated with declines in memory and executive functioning over 6 years via relatively higher levels of CRP. Our results suggest that systemic inflammation is one biologically plausible mechanism through which differences in body mass might influence changes in cognitive functioning among aging adults.
Note12 month embargo; Available online 19 September 2016.
VersionFinal accepted manuscript
SponsorsNational Institute of Aging in the United States; UK government departments