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    In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans

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    Name:
    Frankl_Lipolysis_Weight_Gain_M ...
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    136.7Kb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
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    Author
    Frankl, Joseph cc
    Piaggi, Paolo cc
    Foley, James E.
    Krakoff, Jonathan
    Votruba, Susanne B.
    Affiliation
    University of Arizona College of Medicine
    Issue Date
    2017-01
    
    Metadata
    Show full item record
    Publisher
    WILEY-BLACKWELL
    Citation
    In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans 2017, 25 (1):207 Obesity
    Journal
    Obesity
    Rights
    © 2016 The Obesity Society.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Objective: To assess the association of adipocyte size with cellular lipolysis and between cellular lipolysis and whole-body lipid oxidation. This study also assessed the association between adipocyte size and cellular lipolysis with weight and fat mass gain. Methods: Subjects had assessment of percent body fat (% fat) and adipose tissue biopsy for in vitro lipolysis (n = 325), and a subset of subjects had measurement of whole-body lipid oxidation (n = 112). A subset of subjects (n = 243) returned for repeated measurements of body weight and composition (mean follow-up 8.2 +/- 5.5 years). Results: In vitro lipolysis (r = 0.47, P < 0.0001) and adipocyte size (r = 0.49, P < 0.0001) were strongly associated with % fat. In vitro lipolysis (P = 0.04) but not adipocyte size (P = 0.44) was associated with whole-body fat oxidation. Adipocyte size was not associated with rate of percent weight gain (P = 0.20) but was negatively associated with rate of percent fat mass gain (P = 0.01). In vitro lipolysis was negatively associated with rate of percent weight gain (P = 0.02) and had a marginal negative association with rate of percent fat mass gain (P = 0.08). Conclusions: These results indicate inherent characteristics of adipocytes, including size and lipolytic activity, may be important determinants of whole-body lipid oxidation and subsequent weight gain.
    Note
    12 month embargo; Version of record online: 21 November 2016
    ISSN
    19307381
    DOI
    10.1002/oby.21670
    Version
    Final accepted manuscript
    Sponsors
    Intramural Research Program of the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
    Additional Links
    http://doi.wiley.com/10.1002/oby.21670
    ae974a485f413a2113503eed53cd6c53
    10.1002/oby.21670
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