In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans
AffiliationUniversity of Arizona College of Medicine
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CitationIn Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans 2017, 25 (1):207 Obesity
Rights© 2016 The Obesity Society
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AbstractObjective: To assess the association of adipocyte size with cellular lipolysis and between cellular lipolysis and whole-body lipid oxidation. This study also assessed the association between adipocyte size and cellular lipolysis with weight and fat mass gain. Methods: Subjects had assessment of percent body fat (% fat) and adipose tissue biopsy for in vitro lipolysis (n = 325), and a subset of subjects had measurement of whole-body lipid oxidation (n = 112). A subset of subjects (n = 243) returned for repeated measurements of body weight and composition (mean follow-up 8.2 +/- 5.5 years). Results: In vitro lipolysis (r = 0.47, P < 0.0001) and adipocyte size (r = 0.49, P < 0.0001) were strongly associated with % fat. In vitro lipolysis (P = 0.04) but not adipocyte size (P = 0.44) was associated with whole-body fat oxidation. Adipocyte size was not associated with rate of percent weight gain (P = 0.20) but was negatively associated with rate of percent fat mass gain (P = 0.01). In vitro lipolysis was negatively associated with rate of percent weight gain (P = 0.02) and had a marginal negative association with rate of percent fat mass gain (P = 0.08). Conclusions: These results indicate inherent characteristics of adipocytes, including size and lipolytic activity, may be important determinants of whole-body lipid oxidation and subsequent weight gain.
Note12 month embargo; Version of record online: 21 November 2016
VersionFinal accepted manuscript
SponsorsIntramural Research Program of the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases