In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans
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Frankl_Lipolysis_Weight_Gain_M ...
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Final Accepted Manuscript
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University of Arizona College of MedicineIssue Date
2017-01
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WILEY-BLACKWELLCitation
In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans 2017, 25 (1):207 ObesityJournal
ObesityRights
© 2016 The Obesity Society.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Objective: To assess the association of adipocyte size with cellular lipolysis and between cellular lipolysis and whole-body lipid oxidation. This study also assessed the association between adipocyte size and cellular lipolysis with weight and fat mass gain. Methods: Subjects had assessment of percent body fat (% fat) and adipose tissue biopsy for in vitro lipolysis (n = 325), and a subset of subjects had measurement of whole-body lipid oxidation (n = 112). A subset of subjects (n = 243) returned for repeated measurements of body weight and composition (mean follow-up 8.2 +/- 5.5 years). Results: In vitro lipolysis (r = 0.47, P < 0.0001) and adipocyte size (r = 0.49, P < 0.0001) were strongly associated with % fat. In vitro lipolysis (P = 0.04) but not adipocyte size (P = 0.44) was associated with whole-body fat oxidation. Adipocyte size was not associated with rate of percent weight gain (P = 0.20) but was negatively associated with rate of percent fat mass gain (P = 0.01). In vitro lipolysis was negatively associated with rate of percent weight gain (P = 0.02) and had a marginal negative association with rate of percent fat mass gain (P = 0.08). Conclusions: These results indicate inherent characteristics of adipocytes, including size and lipolytic activity, may be important determinants of whole-body lipid oxidation and subsequent weight gain.Note
12 month embargo; Version of record online: 21 November 2016ISSN
19307381Version
Final accepted manuscriptSponsors
Intramural Research Program of the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney DiseasesAdditional Links
http://doi.wiley.com/10.1002/oby.21670ae974a485f413a2113503eed53cd6c53
10.1002/oby.21670