• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Comparison of Coronary Artery Calcium Scores Between Patients With Psoriasis and Type 2 Diabetes

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    doi160043.pdf
    Size:
    259.4Kb
    Format:
    PDF
    Description:
    Final Published Version
    Download
    Author
    Mansouri, Bobbak
    Kivelevitch, Dario
    Natarajan, Balaji
    Joshi, Aditya A.
    Ryan, Caitriona
    Benjegerdes, Katie
    Schussler, Jeffrey M.
    Rader, Daniel J.
    Reilly, Muredach P.
    Menter, Alan
    Mehta, Nehal N.
    Show allShow less
    Affiliation
    Univ Arizona, Coll Med South Campus
    Issue Date
    2016-11-01
    
    Metadata
    Show full item record
    Publisher
    AMER MEDICAL ASSOC
    Citation
    Comparison of Coronary Artery Calcium Scores Between Patients With Psoriasis and Type 2 Diabetes 2016, 152 (11):1244 JAMA Dermatology
    Journal
    JAMA Dermatology
    Rights
    Copyright 2016 American Medical Association. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    IMPORTANCE Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients with psoriasis has not been compared with other conditions associated with increased cardiovascular risk and more rigorous cardiovascular disease screening, such as type 2 diabetes. OBJECTIVE To assess the burden of asymptomatic coronary atherosclerosis measured by coronary artery calcium score in patients with moderate to severe psoriasis compared with patients with type 2 diabetes and healthy controls. DESIGN, SETTING, AND PARTICIPANTS Three single-center, cross-sectional studies were performed in patients recruited from specialty outpatient clinics with moderate to severe psoriasis without type 2 diabetes (recruited from November 1, 2013, through April 31, 2015), patients with type 2 diabetes without psoriasis or other inflammatory diseases (recruited from July 1, 2009, through June 20, 2011), and age-and sex-matched healthy controls without psoriasis, type 2 diabetes, or other inflammatory diseases (recruited from July 1, 2009, through June 20, 2011). EXPOSURES Psoriasis, type 2 diabetes, and healthy control effect on coronary artery calcium score. MAIN OUTCOMES AND MEASURES Coronary artery calcium measured by Agatston score. RESULTS A total of 387 individuals participated in the study. Mean (SD) age was 51 (7.7), 52 (8.0), and 52 (8.0) years in the psoriasis, type 2 diabetes, and healthy control cohorts, respectively. There were 64 men (49.6%) in each group, and most patients were white (119 [ 92.2%], 123 [ 95.3%], and 128 [ 99.2%] in the psoriasis, type 2 diabetes, and healthy control cohorts, respectively). Patients with psoriasis had low cardiovascular risk measured by the Framingham Risk Score but had a high prevalence of cardiovascular and cardiometabolic risk factors, similar to patients with type 2 diabetes. In a fully adjusted model, psoriasis was associated with coronary artery calcium (Tobit regression ratio, 0.89; P < .001) similar to the association in type 2 diabetes (Tobit regression ratio, 0.79; P = .04). Likelihood ratio testing revealed incremental value for psoriasis in a fully adjusted model (chi(2) = 4.48, P = .03) in predicting coronary artery calcium. Psoriasis was independently associated with the presence of any coronary artery calcium (odds ratio, 2.35; 95% CI, 1.12-4.94) in fully adjusted models, whereas the association of coronary artery calcium with type 2 diabetes was no longer significant after adding body mass index to the model (odds ratio, 2.18; 95% CI, 0.75-6.35). CONCLUSIONS AND RELEVANCE Patients with psoriasis have increased coronary artery calcium by mean total Agatston scores, similar to that of patients with type 2 diabetes, suggesting that patients with psoriasis harbor high rates of subclinical atherosclerosis beyond adjustment for body mass index. Major educational efforts for patients and physicians should be undertaken to reduce the burden of cardiovascular disease in patients with psoriasis.
    Note
    12 month embargo; Published online August 24, 2016.
    ISSN
    2168-6068
    PubMed ID
    27556410
    DOI
    10.1001/jamadermatol.2016.2907
    Version
    Final published version
    Sponsors
    Baylor Heart and Vascular Institute Cardiovascular Research Review Committee; Jack and Jane Hamilton Cardiovascular Research Fund; Intramural Research Program at the National Institutes of Health [HL006193-002]
    Additional Links
    http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jamadermatol.2016.2907
    ae974a485f413a2113503eed53cd6c53
    10.1001/jamadermatol.2016.2907
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • Association between psoriasis and coronary calcium score.
    • Authors: Staniak HL, Bittencourt MS, de Souza Santos I, Sharovsky R, Sabbag C, Goulart AC, Lotufo PA, Benseñor IM
    • Issue date: 2014 Dec
    • Prevalence and severity of coronary artery calcium in young persons with diabetes.
    • Authors: Daga N, Nasir K, Hamirani Y, Tayek J, Bach P, Li D, Budoff MJ
    • Issue date: 2013 Jul-Aug
    • Association Between Changes in Coronary Artery Disease Progression and Treatment With Biologic Agents for Severe Psoriasis.
    • Authors: Hjuler KF, Bøttcher M, Vestergaard C, Bøtker HE, Iversen L, Kragballe K
    • Issue date: 2016 Oct 1
    • Diabetes, subclinical atherosclerosis and multiple cardiovascular risk factors in hard-to-reach asymptomatic patients.
    • Authors: Mamudu HM, Alamian A, Paul T, Subedi P, Wang L, Jones A, Alamin AE, Stewart D, Blackwell G, Budoff M
    • Issue date: 2018 Nov
    • Association of a favorable cardiovascular health profile with the presence of coronary artery calcification.
    • Authors: Saleem Y, DeFina LF, Radford NB, Willis BL, Barlow CE, Gibbons LW, Khera A
    • Issue date: 2015 Jan
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.