Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease
AffiliationDepartment of Pediatrics, University of Arizona
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CitationRelative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease 2016, 58 (1):99 Journal of Applied Genetics
JournalJournal of Applied Genetics
Rights© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2016
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractNicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 (nih) / Npc1 (nih) mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibitor although another HDAC inhibitor, valproic acid, was without effect. Nicotinamide could also work by preventing/reversing oxidative stress.
Note12 month embargo; First Online: 25 October 2016
VersionFinal accepted manuscript
SponsorsWings Like Eagles Foundation, Tucson, AZ
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