Anti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis
AuthorMarsh, Katherine M.
Ferng, Alice S.
Desai, Ankit A.
AffiliationUniv Arizona, Coll Med, Dept Surg, Div Cardiothorac Surg
Univ Arizona, Coll Med, Dept Internal Med, Div Cardiol
Univ Arizona, Coll Med, Dept Med Imaging
Univ Arizona, Coll Med, Dept Physiol Sci
Univ Arizona, Coll Med
Univ Arizona, Coll Med, Dept Translat & Regenerat Med
MetadataShow full item record
PublisherBIOMED CENTRAL LTD
CitationAnti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis 2017, 12 (1) Journal of Cardiothoracic Surgery
Rights© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractBackground: Since constrictive pericarditis is most often idiopathic and the pathophysiology remains largely unknown, both the diagnosis and the treatment can be challenging. However, by definition, inflammatory processes are central to this disease process. Amniotic membrane patches have been shown to possess anti-inflammatory properties and are believed to be immune privileged. Due to these properties, amniotic membrane patches were applied intraoperatively in a complicated patient presenting with constrictive pericarditis. Case presentation: A patient with a history of multiple cardiac surgeries presented with marked fatigue, worsening dyspnea and sinus tachycardia. He was found to have constrictive physiology during cardiac catheterization, with cardiac MRI demonstrating hepatic vein dilatation, atrial enlargement and ventricular narrowing. After amniotic membrane patch treatment and pericardiectomy, post-operative cardiac MRI failed to demonstrate any appreciable pericardial effusion or inflammation, with no increased T2 signal that would suggest edema. Conclusions: Given the positive results seen in this complex patient, we suggest continued research into the beneficial properties of amniotic membrane patches in cardiac surgery.
VersionFinal published version