Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
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Hurley_GQuad_RNA.pdf
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Final Accepted Manuscript
Affiliation
College of Pharmacy and BIO5 Institute, University of ArizonaUniversity of Arizona Cancer Center
Issue Date
2016-11-07Metadata
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NATURE PUBLISHING GROUPCitation
Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA 2016, 13 (1):18 Nature Chemical BiologyJournal
Nature Chemical BiologyRights
Copyright © 2016 Nature America, Inc., part of Springer Nature.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.Note
6 month embargo; Published online 07 November 2016ISSN
1552-44501552-4469