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Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

dc.contributor.authorWeldon, Carika
dc.contributor.authorBehm-Ansmant, Isabelle
dc.contributor.authorHurley, Laurence H
dc.contributor.authorBurley, Glenn A
dc.contributor.authorBranlant, Christiane
dc.contributor.authorEperon, Ian C
dc.contributor.authorDominguez, Cyril
dc.date.accessioned2017-04-10T21:42:03Z
dc.date.available2017-04-10T21:42:03Z
dc.date.issued2016-11-07
dc.identifier.citationIdentification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA 2016, 13 (1):18 Nature Chemical Biologyen
dc.identifier.issn1552-4450
dc.identifier.issn1552-4469
dc.identifier.pmid27820800
dc.identifier.doi10.1038/nchembio.2228
dc.identifier.urihttp://hdl.handle.net/10150/623077
dc.description.abstractRNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.
dc.description.sponsorshipMedical Research Council Career Development Award [G1000526]; Bank of Butterfield Foundation in Bermuda; Lorraine University [UMR 7365]; European Alternative Splicing Network of Excellence (EURASNET, FP6 life sciences, genomics and biotechnology for health) [LSHG-CT-2005-518238]; CNRSen
dc.language.isoenen
dc.publisherNATURE PUBLISHING GROUPen
dc.relation.urlhttp://www.nature.com/doifinder/10.1038/nchembio.2228en
dc.rightsCopyright © 2016 Nature America, Inc., part of Springer Nature.en
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleIdentification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNAen
dc.typeArticleen
dc.contributor.departmentCollege of Pharmacy and BIO5 Institute, University of Arizonaen
dc.contributor.departmentUniversity of Arizona Cancer Centeren
dc.identifier.journalNature Chemical Biologyen
dc.description.note6 month embargo; Published online 07 November 2016en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal accepted manuscripten
refterms.dateFOA2017-05-08T00:00:00Z
html.description.abstractRNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.


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