Genetics: Implications for Prevention and Management of Coronary Artery Disease
AffiliationInternational Society for Cardiovascular Translational Research, University of Arizona College of Medicine
MetadataShow full item record
PublisherELSEVIER SCIENCE INC
CitationGenetics: Implications for Prevention and Management of Coronary Artery Disease 2016, 68 (25):2797 Journal of the American College of Cardiology
Rights© 2016 by the American College of Cardiology Foundation. Published by Elsevier.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractAn exciting new era has dawned for the prevention and management of CAD utilizing genetic risk variants. The recent identification of over 60 susceptibility loci for coronary artery disease (CAD) confirm not only the importance of established risk factors, but also the existence of many novel causal pathways that are expected to improve our understanding of the genetic basis of CAD and facilitate the development of new therapeutic agents over time. Concurrently, Mendelian randomization studies have provided intriguing insights on the causal relationship between CAD-related traits, and highlight the potential benefits of long-term modifications of risk factors. Lastly, genetic risk scores of CAD may serve not only as prognostic, but also as predictive markers and carry the potential to considerably improve the delivery of established prevention strategies. This review will summarize the evolution and discovery of genetic risk variants for CAD and their current and future clinical applications.
Note12 month embargo; Available online 19 December 2016
VersionFinal accepted manuscript