Gait changes in a line of mice artificially selected for longer limbs
Author
Sparrow, Leah M.Pellatt, Emily
Yu, Sabrina S.
Raichlen, David A.
Pontzer, Herman
Rolian, Campbell
Affiliation
Univ Arizona, Sch AnthropolIssue Date
2017-02-22
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PEERJ INCCitation
Gait changes in a line of mice artificially selected for longer limbs 2017, 5:e3008 PeerJJournal
PeerJRights
Copyright 2017 Sparrow et al. Distributed under Creative Commons CC-BY 4.0Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
In legged terrestrial locomotion, the duration of stance phase, i.e., when limbs are in contact with the substrate, is positively correlated with limb length, and negatively correlated with the metabolic cost of transport. These relationships are well documented at the interspecific level, across a broad range of body sizes and travel speeds. However, such relationships are harder to evaluate within species (i.e., where natural selection operates), largely for practical reasons, including low population variance in limb length, and the presence of confounding factors such as body mass, or training. Here, we compared spatiotemporal kinematics of gait in Longshanks, a long-legged mouse line created through artificial selection, and in random-bred, mass-matched Control mice raised under identical conditions. We used a gait treadmill to test the hypothesis that Longshanks have longer stance phases and stride lengths, and decreased stride frequencies in both fore- and hind limbs, compared with Controls. Our results indicate that gait differs significantly between the two groups. Specifically, and as hypothesized, stance duration and stride length are 8–10% greater in Longshanks, while stride frequency is 8% lower than in Controls. However, there was no difference in the touch-down timing and sequence of the paws between the two lines. Taken together, these data suggest that, for a given speed, Longshanks mice take significantly fewer, longer steps to cover the same distance or running time compared to Controls, with important implications for other measures of variation among individuals in whole-organism performance, such as the metabolic cost of transport.ISSN
2167-8359PubMed ID
28243533Version
Final published versionSponsors
Queen Elizabeth II Scholarship from the University of Calgary; Markin Undergraduate Summer Research Program; Heritage Youth Researcher Summer (HYRS) program from Alberta Innovates Health Solutions; Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC); Faculty of Veterinary Medicine at the University of CalgaryAdditional Links
https://peerj.com/articles/3008ae974a485f413a2113503eed53cd6c53
10.7717/peerj.3008
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