Gait changes in a line of mice artificially selected for longer limbs
AuthorSparrow, Leah M.
Yu, Sabrina S.
Raichlen, David A.
AffiliationUniv Arizona, Sch Anthropol
MetadataShow full item record
CitationGait changes in a line of mice artificially selected for longer limbs 2017, 5:e3008 PeerJ
RightsCopyright 2017 Sparrow et al. Distributed under Creative Commons CC-BY 4.0
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractIn legged terrestrial locomotion, the duration of stance phase, i.e., when limbs are in contact with the substrate, is positively correlated with limb length, and negatively correlated with the metabolic cost of transport. These relationships are well documented at the interspecific level, across a broad range of body sizes and travel speeds. However, such relationships are harder to evaluate within species (i.e., where natural selection operates), largely for practical reasons, including low population variance in limb length, and the presence of confounding factors such as body mass, or training. Here, we compared spatiotemporal kinematics of gait in Longshanks, a long-legged mouse line created through artificial selection, and in random-bred, mass-matched Control mice raised under identical conditions. We used a gait treadmill to test the hypothesis that Longshanks have longer stance phases and stride lengths, and decreased stride frequencies in both fore- and hind limbs, compared with Controls. Our results indicate that gait differs significantly between the two groups. Specifically, and as hypothesized, stance duration and stride length are 8–10% greater in Longshanks, while stride frequency is 8% lower than in Controls. However, there was no difference in the touch-down timing and sequence of the paws between the two lines. Taken together, these data suggest that, for a given speed, Longshanks mice take significantly fewer, longer steps to cover the same distance or running time compared to Controls, with important implications for other measures of variation among individuals in whole-organism performance, such as the metabolic cost of transport.
VersionFinal published version
SponsorsQueen Elizabeth II Scholarship from the University of Calgary; Markin Undergraduate Summer Research Program; Heritage Youth Researcher Summer (HYRS) program from Alberta Innovates Health Solutions; Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC); Faculty of Veterinary Medicine at the University of Calgary
- Selective Breeding and Short-Term Access to a Running Wheel Alter Stride Characteristics in House Mice.
- Authors: Claghorn GC, Thompson Z, Kay JC, Ordonez G, Hampton TG, Garland T Jr
- Issue date: 2017 Sep/Oct
- Standardised terminology for the description and analysis of equine locomotion.
- Authors: Leach DH, Ormrod K, Clayton HM
- Issue date: 1984 Nov
- The locomotor kinematics of Asian and African elephants: changes with speed and size.
- Authors: Hutchinson JR, Schwerda D, Famini DJ, Dale RH, Fischer MS, Kram R
- Issue date: 2006 Oct
- Changes in shape and cross-sectional geometry in the tibia of mice selectively bred for increases in relative bone length.
- Authors: Cosman MN, Sparrow LM, Rolian C
- Issue date: 2016 Jun
- Selection for longer limbs in mice increases bone stiffness and brittleness, but does not alter bending strength.
- Authors: Cosman MN, Britz HM, Rolian C
- Issue date: 2019 May 10