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dc.contributor.authorSparrow, Leah M.
dc.contributor.authorPellatt, Emily
dc.contributor.authorYu, Sabrina S.
dc.contributor.authorRaichlen, David A.
dc.contributor.authorPontzer, Herman
dc.contributor.authorRolian, Campbell
dc.date.accessioned2017-04-24T19:43:52Z
dc.date.available2017-04-24T19:43:52Z
dc.date.issued2017-02-22
dc.identifier.citationGait changes in a line of mice artificially selected for longer limbs 2017, 5:e3008 PeerJen
dc.identifier.issn2167-8359
dc.identifier.pmid28243533
dc.identifier.doi10.7717/peerj.3008
dc.identifier.urihttp://hdl.handle.net/10150/623229
dc.description.abstractIn legged terrestrial locomotion, the duration of stance phase, i.e., when limbs are in contact with the substrate, is positively correlated with limb length, and negatively correlated with the metabolic cost of transport. These relationships are well documented at the interspecific level, across a broad range of body sizes and travel speeds. However, such relationships are harder to evaluate within species (i.e., where natural selection operates), largely for practical reasons, including low population variance in limb length, and the presence of confounding factors such as body mass, or training. Here, we compared spatiotemporal kinematics of gait in Longshanks, a long-legged mouse line created through artificial selection, and in random-bred, mass-matched Control mice raised under identical conditions. We used a gait treadmill to test the hypothesis that Longshanks have longer stance phases and stride lengths, and decreased stride frequencies in both fore- and hind limbs, compared with Controls. Our results indicate that gait differs significantly between the two groups. Specifically, and as hypothesized, stance duration and stride length are 8–10% greater in Longshanks, while stride frequency is 8% lower than in Controls. However, there was no difference in the touch-down timing and sequence of the paws between the two lines. Taken together, these data suggest that, for a given speed, Longshanks mice take significantly fewer, longer steps to cover the same distance or running time compared to Controls, with important implications for other measures of variation among individuals in whole-organism performance, such as the metabolic cost of transport.
dc.description.sponsorshipQueen Elizabeth II Scholarship from the University of Calgary; Markin Undergraduate Summer Research Program; Heritage Youth Researcher Summer (HYRS) program from Alberta Innovates Health Solutions; Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC); Faculty of Veterinary Medicine at the University of Calgaryen
dc.language.isoenen
dc.publisherPEERJ INCen
dc.relation.urlhttps://peerj.com/articles/3008en
dc.rightsCopyright 2017 Sparrow et al. Distributed under Creative Commons CC-BY 4.0en
dc.subjectStanceen
dc.subjectStride lengthen
dc.subjectGaiten
dc.subjectLongshanksen
dc.subjectLimb lengthen
dc.titleGait changes in a line of mice artificially selected for longer limbsen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Sch Anthropolen
dc.identifier.journalPeerJen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
dc.contributor.institutionDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
dc.contributor.institutionDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
dc.contributor.institutionCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
dc.contributor.institutionSchool of Anthropology, University of Arizona, Tucson, AZ, United States
dc.contributor.institutionDepartment of Anthropology, City University of New York, Hunter College, New York, NY, United States
dc.contributor.institutionDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
refterms.dateFOA2018-07-18T00:44:22Z
html.description.abstractIn legged terrestrial locomotion, the duration of stance phase, i.e., when limbs are in contact with the substrate, is positively correlated with limb length, and negatively correlated with the metabolic cost of transport. These relationships are well documented at the interspecific level, across a broad range of body sizes and travel speeds. However, such relationships are harder to evaluate within species (i.e., where natural selection operates), largely for practical reasons, including low population variance in limb length, and the presence of confounding factors such as body mass, or training. Here, we compared spatiotemporal kinematics of gait in Longshanks, a long-legged mouse line created through artificial selection, and in random-bred, mass-matched Control mice raised under identical conditions. We used a gait treadmill to test the hypothesis that Longshanks have longer stance phases and stride lengths, and decreased stride frequencies in both fore- and hind limbs, compared with Controls. Our results indicate that gait differs significantly between the two groups. Specifically, and as hypothesized, stance duration and stride length are 8–10% greater in Longshanks, while stride frequency is 8% lower than in Controls. However, there was no difference in the touch-down timing and sequence of the paws between the two lines. Taken together, these data suggest that, for a given speed, Longshanks mice take significantly fewer, longer steps to cover the same distance or running time compared to Controls, with important implications for other measures of variation among individuals in whole-organism performance, such as the metabolic cost of transport.


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