Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21 st International Symposium on Microsomes and Drug Oxidations (MDO)
Cherrington, Nathan J.
Aleksunes, Lauren M.
Zanger, Ulrich M.
Morgan, Edward M.
Turnbaugh, Peter J.
Klaassen, Curtis D.
Bhatt, Aadra P.
Redinbo, Matthew R.
Waxman, David J.
AffiliationUniv Arizona, Coll Pharm, Dept Pharmaceut Sci
KeywordsDrug metabolism toxicity
Long non-coding RNAs
MetadataShow full item record
CitationRegulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21 st International Symposium on Microsomes and Drug Oxidations (MDO) 2017, 7 (2):241 Acta Pharmaceutica Sinica B
JournalActa Pharmaceutica Sinica B
Rights© 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractVariations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2-6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research. (C) 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
NoteOpen Access Journal.
VersionFinal published version
SponsorsU.S. National Institutes of Health (NIH) [U01CA175315, R01GM113888]; NIH [ES006694, ES007091, ES021800, ES020522, ES005022, ES023438, DK083952, R01HL122593, R01ES025708, CA098468, T32DK007737, R01DK33765, R01ES024421, R01DK104656, R01DK080440, R01ES025909, R21AA022482, R21AA024935, R01ES019487, R01GM087367, R01GM118367]; Robert Bosch Foundation, Stuttgart, Germany; Searle Scholars Program, USA; VA Merit Award, USA [1I01BX002634]; National Natural Science Foundation of China ; Yale Liver Center, USA [P30 DK34989]; Amgen; Genentech; Gilead; Pfizer; Bristol-Myers Squibb; UC Davis
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