• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    jamaneurology_Zissimopoulos_20 ...
    Size:
    305.9Kb
    Format:
    PDF
    Description:
    Final Published Version
    Download
    Author
    Zissimopoulos, Julie M.
    Barthold, Douglas
    Brinton, Roberta Diaz
    Joyce, Geoffrey
    Affiliation
    Univ Arizona Hlth Sci, Ctr Innovat Brain Sci
    Issue Date
    2017-02-01
    
    Metadata
    Show full item record
    Publisher
    AMER MEDICAL ASSOC
    Citation
    Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease 2017, 74 (2):225 JAMA Neurology
    Journal
    JAMA Neurology
    Rights
    Copyright 2017 American Medical Association. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    IMPORTANCE To our knowledge, no effective treatments exist for Alzheimer disease, and new molecules are years away. However, several drugs prescribed for other conditions have been associated with reducing its risk. OBJECTIVE To analyze the association between statin exposure and Alzheimer disease incidence among Medicare beneficiaries. DESIGN, SETTING, AND PARTICIPANTS We examined the medical and pharmacy claims of a 20% sample of Medicare beneficiaries from 2006 to 2013 and compared rates of Alzheimer disease diagnosis for 399979 statin users 65 years of age or older with high or low exposure to statins and with drug molecules for black, Hispanic, and non-Hispanic white people, and men and women of Asian, Native American, or unkown race/ethnicity who are referred to as "other." MAIN OUTCOMES AND MEASURES The main outcome was incident diagnosis of Alzheimer disease based on the International Classification of Diseases, Ninth Revision, Clinical Modification. We used Cox proportional hazard models to analyze the association between statin exposure and Alzheimer disease diagnosis for different sexes, races and ethnicities, and statin molecules. RESULTS The 399979 study participants included 7794 (1.95%) black men, 24484 (6.12%) black women, 11200 (2.80%) Hispanic men, 21458 (5.36%) Hispanic women, 115059 (28.77%) white men, and 195181 (48.80%) white women. High exposure to statins was associated with a lower risk of Alzheimer disease diagnosis for women (hazard ratio [HR], 0.85; 95% CI, 0.82-0.89; P<. 001) and men (HR, 0.88; 95% CI, 0.83-0.93; P<.001). Simvastatin was associated with lower Alzheimer disease risk for white women (HR, 0.86; 95% CI, 0.81-0.92; P<.001), white men (HR, 0.90; 95% CI, 0.82-0.99; P=.02), Hispanic women (HR, 0.82; 95% CI, 0.68-0.99; P=.04), Hispanic men (HR, 0.67; 95% CI,0.50-0.91; P=.01), and black women (HR, 0.78; 95% CI, 0.66-0.93; P=.005). Atorvastatin was associated with a reduced risk of incident Alzheimer disease diagnosis for white women (HR, 0.84, 95% CI, 0.78-0.89), black women (HR, 0.81, 95% CI, 0.67-0.98), and Hispanic men (HR, 0.61, 95% CI, 0.42-0.89) and women (HR, 0.76, 95% CI, 0.60-0.97).Pravastatin and rosuvastatin were associated with reduced Alzheimer disease risk for white women only (HR, 0.82, 95% CI, 0.70-0.95 and HR, 0.81, 95% CI, 0.67-0.98, respectively). High statin exposure was not associated with a statistically significant lower Alzheimer disease risk among black men. CONCLUSIONS AND RELEVANCE The reduction in Alzheimer disease risk varied across statin molecules, sex, and race/ethnicity. Clinical trials that include racial and ethnic groups need to confirm these findings. Because statins may affect Alzheimer disease risk, physicians should consider which statin is prescribed to each patient.
    Note
    12 month embargo; Published Online: December 12, 2016.
    ISSN
    2168-6149
    PubMed ID
    27942728
    DOI
    10.1001/jamaneurol.2016.3783
    Version
    Final published version
    Sponsors
    National Institute on Aging of the National Institutes of Health [1RC4AG039036-01, P30AG043073-01]; University of Southern California Zumberge Research Fund [1R34AG049652]; Amgen
    Additional Links
    http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jamaneurol.2016.3783
    ae974a485f413a2113503eed53cd6c53
    10.1001/jamaneurol.2016.3783
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • Differences in breast cancer stage at diagnosis and cancer-specific survival by race and ethnicity in the United States.
    • Authors: Iqbal J, Ginsburg O, Rochon PA, Sun P, Narod SA
    • Issue date: 2015 Jan 13
    • Difference in Association of Obesity With Prostate Cancer Risk Between US African American and Non-Hispanic White Men in the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
    • Authors: Barrington WE, Schenk JM, Etzioni R, Arnold KB, Neuhouser ML, Thompson IM Jr, Lucia MS, Kristal AR
    • Issue date: 2015 Jun
    • Association of Modifiable Risk Factors in Young Adulthood With Racial Disparity in Incident Type 2 Diabetes During Middle Adulthood.
    • Authors: Bancks MP, Kershaw K, Carson AP, Gordon-Larsen P, Schreiner PJ, Carnethon MR
    • Issue date: 2017 Dec 26
    • Racial/Ethnic and gender gaps in the use of and adherence to evidence-based preventive therapies among elderly Medicare Part D beneficiaries after acute myocardial infarction.
    • Authors: Lauffenburger JC, Robinson JG, Oramasionwu C, Fang G
    • Issue date: 2014 Feb 18
    • Association of combination statin and antihypertensive therapy with reduced Alzheimer's disease and related dementia risk.
    • Authors: Barthold D, Joyce G, Diaz Brinton R, Wharton W, Kehoe PG, Zissimopoulos J
    • Issue date: 2020
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.