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    Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques

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    Author
    DiNapoli, Sarah R.
    Ortiz, Alexandra M.
    Wu, Fan
    Matsuda, Kenta
    Twigg, Homer L.
    Hirsch, Vanessa M.
    Knox, Kenneth
    Brenchley, Jason M.
    Affiliation
    Univ Arizona, Dept Med
    Issue Date
    2017-02-23
    
    Metadata
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    Publisher
    AMER SOC CLINICAL INVESTIGATION INC
    Citation
    Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques 2017, 2 (4) JCI Insight
    Journal
    JCI Insight
    Rights
    Copyright © 2017, American Society for Clinical Investigation.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    SIV DNA can be detected in lymphoid tissue-resident macrophages of chronically SIV-infected Asian macaques. These macrophages also contain evidence of recently phagocytosed SIV-infected CD4(+) T cells. Here, we examine whether these macrophages contain replication-competent virus, whether viral DNA can be detected in tissue-resident macrophages from antiretroviral (ARV) therapy-treated animals and humans, and how the viral sequences amplified from macrophages and contemporaneous CD4(+) T cells compare. In ARV-naive animals, we find that lymphoid tissue-resident macrophages contain replication-competent virus if they also contain viral DNA in ARV-naive Asian macaques. The genetic sequence of the virus within these macrophages is similar to those within CD4(+) T cells from the same anatomic sites. In ARV-treated animals, we find that viral DNA can be amplified from lymphoid tissue-resident macrophages of SIV-infected Asian macaques that were treated with ARVs for at least 5 months, but we could not detect replicationcompetent virus from macrophages of animals treated with ARVs. Finally, we could not detect viral DNA in alveolar macrophages from HIV-infected individuals who received ARVs for 3 years and had undetectable viral loads. These data demonstrate that macrophages can contain replicationcompetent virus, but may not represent a significant reservoir for HIV in vivo.
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    Authors can deposit to institutional repositories, and we request that they deposit the final, published JCI Insight version.
    ISSN
    2379-3708
    PubMed ID
    28239657
    DOI
    10.1172/jci.insight.91214
    Version
    Final published version
    Sponsors
    Division of Intramural Research/NIAID/NIH
    Additional Links
    https://insight.jci.org/articles/view/91214
    ae974a485f413a2113503eed53cd6c53
    10.1172/jci.insight.91214
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