The neonatal methylome as a gatekeeper in the trajectory to childhood asthma
AffiliationGraduate Program in Cellular & Molecular Medicine, University of Arizona
Asthma & Airway Disease Research Center, University of Arizona
Arizona Center for the Biology of Complex Diseases, University of Arizona
Department of Cellular & Molecular Medicine, University of Arizona
The Bio5 Institute, University of Arizona
MetadataShow full item record
PublisherFUTURE MEDICINE LTD
CitationThe neonatal methylome as a gatekeeper in the trajectory to childhood asthma 2017, 9 (4):585 Epigenomics
Rights© 2017 Future Medicine Ltd
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractAsthma is a heterogeneous group of conditions that typically begin in early life and result in recurrent, reversible bronchial obstruction. The role played by epigenetic mechanisms in the pathogenesis of childhood asthma is understood only in part. Here we discuss asthma epigenetics within a developmental perspective based on our recent demonstration that the epigenetic trajectory to childhood asthma begins at birth. We next discuss how this trajectory may be affected by prenatal environmental exposures. Finally, we examine in vitro studies that model the impact of asthma-associated exposures on the epigenome. All of these studies specifically surveyed human DNA methylation and involved a genome-wide component. In combination, their results broaden our understanding of asthma pathogenesis and the role the methylome plays in this process.
Note12 month embargo; published April 2017
VersionFinal accepted manuscript