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dc.contributor.authorNorris, Gregory
dc.date.accessioned2017-05-26T20:41:48Z
dc.date.available2017-05-26T20:41:48Z
dc.date.issued2017-05-26
dc.identifier.urihttp://hdl.handle.net/10150/623631
dc.descriptionA Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.en
dc.description.abstractAtypical teratoid rhabdoid tumor (ATRT) is a highly malignant pediatric central nervous system tumor. The prognosis is often poor, with a 2‐year survival rate estimated at 15%. This dismal prognosis highlights the need to develop new treatment modalities for this devastating pediatric tumor. Recently, a tumor suppressing signaling pathway known as Hippo has emerged as a possible cancer treatment target. The Hippo signaling pathway is involved in organ growth and maintenance, and is dysregulated in many diverse cancers. We used quantitative real‐time PCR to evaluate the mRNA expression profile of Hippo pathway genes. We then used determined the protein expression of various Hippo components using Western blots. The results of this study suggest that Hippo plays a definite role in atypical teratoid rhabdoid tumor.
dc.language.isoen_USen
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the College of Medicine - Phoenix, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectCanceren
dc.subjectPediatricen
dc.subjectBrain Tumoren
dc.subjectAtypical Teratoid Rhabdoid Tumoren
dc.subjectHippo Signaling Pathwayen
dc.subjectVerteporfinen
dc.subject.meshBrain Neoplasmsen
dc.subject.meshChilden
dc.subject.meshPolymerase Chain Reactionen
dc.subject.meshSequence Analysis, RNAen
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshGene Expressionen
dc.subject.meshTreatment Outcomeen
dc.titleTargeting the Hippo Signaling Pathway in Atypical Teratoid Rhabdoid Tumoren_US
dc.typetext; Electronic Thesisen
dc.contributor.departmentThe University of Arizona College of Medicine - Phoenixen
dc.description.collectioninformationThis item is part of the College of Medicine - Phoenix Scholarly Projects 2017 collection. For more information, contact the Phoenix Biomedical Campus Library at pbc-library@email.arizona.edu.en_US
dc.contributor.mentorBhardwaj, Ratanen
refterms.dateFOA2018-09-11T19:39:36Z
html.description.abstractAtypical teratoid rhabdoid tumor (ATRT) is a highly malignant pediatric central nervous system tumor. The prognosis is often poor, with a 2‐year survival rate estimated at 15%. This dismal prognosis highlights the need to develop new treatment modalities for this devastating pediatric tumor. Recently, a tumor suppressing signaling pathway known as Hippo has emerged as a possible cancer treatment target. The Hippo signaling pathway is involved in organ growth and maintenance, and is dysregulated in many diverse cancers. We used quantitative real‐time PCR to evaluate the mRNA expression profile of Hippo pathway genes. We then used determined the protein expression of various Hippo components using Western blots. The results of this study suggest that Hippo plays a definite role in atypical teratoid rhabdoid tumor.


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