Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation
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Univ Arizona, Coll Med, Dept Internal Med, Banner Univ Med CtrIssue Date
2017-04
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DOVE MEDICAL PRESS LTDCitation
Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation 2017, Volume 10:973 Journal of Pain ResearchJournal
Journal of Pain ResearchRights
© 2017 Low et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
A 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotide, and dantrolene, all providing 24-48 hours of relief followed by symptom flare. Interventional therapies, including peripheral and sympathetic ganglion blocks, also failed. Thus far, clonidine and ketamine have been the only effective agents for our patient. Genetic testing was negative for an EM-associated mutation in the SCN9A gene, encoding the Na(V)1.7 sodium channel, suggesting a mutation in an alternate gene.Note
Open Access JournalISSN
1178-7090PubMed ID
28490900Version
Final published versionSponsors
Foundation for Anesthesia Education and Research (FAER)Additional Links
https://www.dovepress.com/complex-management-of-a-patient-with-refractory-primary-erythromelalgi-peer-reviewed-article-JPRae974a485f413a2113503eed53cd6c53
10.2147/JPR.S129661
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