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dc.contributor.authorLow, Sarahen
dc.contributor.authorRobbins, Wendyeen
dc.contributor.authorTawfik, Vivianneen
dc.date.accessioned2017-06-13T19:02:28Z
dc.date.available2017-06-13T19:02:28Z
dc.date.issued2017-04
dc.identifier.citationComplex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation 2017, Volume 10:973 Journal of Pain Researchen
dc.identifier.issn1178-7090
dc.identifier.pmid28490900
dc.identifier.doi10.2147/JPR.S129661
dc.identifier.urihttp://hdl.handle.net/10150/624081
dc.description.abstractA 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotide, and dantrolene, all providing 24-48 hours of relief followed by symptom flare. Interventional therapies, including peripheral and sympathetic ganglion blocks, also failed. Thus far, clonidine and ketamine have been the only effective agents for our patient. Genetic testing was negative for an EM-associated mutation in the SCN9A gene, encoding the Na(V)1.7 sodium channel, suggesting a mutation in an alternate gene.
dc.description.sponsorshipFoundation for Anesthesia Education and Research (FAER)en
dc.language.isoenen
dc.publisherDOVE MEDICAL PRESS LTDen
dc.relation.urlhttps://www.dovepress.com/complex-management-of-a-patient-with-refractory-primary-erythromelalgi-peer-reviewed-article-JPRen
dc.rights© 2017 Low et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/).en
dc.subjecterythromelalgiaen
dc.subjectchronic painen
dc.subjectgenetic testingen
dc.subjectsodium channelsen
dc.subjectketamineen
dc.titleComplex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutationen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Coll Med, Dept Internal Med, Banner Univ Med Ctren
dc.identifier.journalJournal of Pain Researchen
dc.description.noteOpen Access Journalen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
refterms.dateFOA2018-09-11T20:01:07Z
html.description.abstractA 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotide, and dantrolene, all providing 24-48 hours of relief followed by symptom flare. Interventional therapies, including peripheral and sympathetic ganglion blocks, also failed. Thus far, clonidine and ketamine have been the only effective agents for our patient. Genetic testing was negative for an EM-associated mutation in the SCN9A gene, encoding the Na(V)1.7 sodium channel, suggesting a mutation in an alternate gene.


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