• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Master's Theses
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Master's Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Impact of Single Dose Systemic Glucocorticoids on Blood Leukocytes In Hospitalized Adults

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_etd_15495_sip1_m.pdf
    Size:
    498.5Kb
    Format:
    PDF
    Description:
    Thesis not available in UA Campus ...
    Download
    Author
    Alshehri, Samah
    Issue Date
    2017
    Keywords
    glucocorticoid
    leukocytosis
    Steroid
    white blood cell
    Advisor
    Katz, Michael
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Embargo
    Thesis not available (per author's request)
    Abstract
    Background: Glucocorticoids (GCs) may cause leukocytosis via several mechanisms. This study was conducted to examine the impact of a single dose of systemic GCs on total white blood cell count (WBC), absolute neutrophilic count (ANC), and absolute lymphocytic count (ALC) in hospitalized adults without bacterial infections. Methods: This retrospective cohort study was carried out in a university hospital. Hospitalized patients 18 years of age or older who received a single dose of a systemic GC were included. Baseline blood cell counts prior to GC administration were required for subjects to be included in the study. Glucocorticoids included in this study were oral or intravenous methylprednisolone and hydrocortisone and oral prednisone. Results: A total of 99 patients were included in the study. After the administration of a single GC dose, ALC began to drop significantly as early as the interval of 0 - <6 hours [median (IQR), 0.90 (0.60-1.10), P=0.011]. ANC increased significantly as early as the interval of 6 - <12 hours [median (IQR), 6.22 (4.45-7.33), P=0.049] and continued to be significantly increased from baseline up to 42 hours from GC administration. Total WBC counts significantly decreased in the 6 - <12 hours interval [median(IQR), 6.90 (5.15-8.85) P=0.03] and then increased significantly in the12 - <18 hours interval [median(IQR), 8.80 (6.50-11.95), P= 0.002]. This effect on total WBC count continued to be significant until the 36 - <42 hours interval [median (IQR), 10.55 (7.23-13.03), P<0.001] Conclusion: ANC, followed by WBC count increase significantly after a single dose administration of GC in hospitalized patients within 12 hours of a single GC dose. Variability in timing and extent of leukocyte and ANC elevation was seen. A decrease in WBC and ALC was seen within the first few hours of GC dose. High doses of GC and autoimmune disease were associated with greater elevation in WBC counts.
    Type
    text
    Electronic Thesis
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Clinical Translational Sciences
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.