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dc.contributor.advisorSlack, Marionen
dc.contributor.authorBurke, Eric
dc.contributor.authorGarvin, Matthew
dc.date.accessioned2017-06-21T17:25:07Z
dc.date.available2017-06-21T17:25:07Z
dc.date.issued2008
dc.identifier.urihttp://hdl.handle.net/10150/624317
dc.descriptionClass of 2008 Abstracten
dc.description.abstractObjectives: To assess the effect of treatment with placebo on weight loss in obese patients. Methods: The placebo groups from nine orlistat and three sibutramine weight loss studies, as identified from the Padwal meta-analysis, were analyzed for: weight loss in kilograms; change in BMI; type of nutrition and exercise interventions; and bias. The means and standard deviations for weight loss were entered into the Stata meta-analysis program to obtain a forest plot to determine an overall estimate of weight loss. The Potential for Methodological Bias Assessment Tool (PMBAT) was used to create a bias score for each study. Results: Overall, subjects in the placebo group lost 3.8 kg (p<0.001). Placebo subjects in the orlistat trials lost significantly more weight (4.3 kg) than did subjects in the sibutramine trials (1.1 kg, p=0.014). The subjects in the sibutramine studies did not lose a significant amount of weight (p=0.397). There were distinct differences between the sibutramine and orlistat studies with regard to nutrition and exercise interventions. The mean score on the PMBAT was 16.7 ± 3.6; and no study scored higher than 25 out of 45 total points. Conclusions: Overall subjects in the placebo group in the combined orlistat and sibutramine studies lost a significant amount of weight. Differences in study design, bias, and the Hawthorne effect may have contributed to this weight loss.
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author.en
dc.subjectWeight Lossen
dc.subjectPlacebosen
dc.subjectObese Patientsen
dc.subjectMeta-Analysisen
dc.subject.meshWeight Lossen
dc.subject.meshPlacebosen
dc.subject.meshObesityen
dc.titleThe Effect of Placebo on Weight Loss in Obese Patients: A Meta-analysisen_US
dc.typetexten
dc.typeElectronic Reporten
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en
html.description.abstractObjectives: To assess the effect of treatment with placebo on weight loss in obese patients. Methods: The placebo groups from nine orlistat and three sibutramine weight loss studies, as identified from the Padwal meta-analysis, were analyzed for: weight loss in kilograms; change in BMI; type of nutrition and exercise interventions; and bias. The means and standard deviations for weight loss were entered into the Stata meta-analysis program to obtain a forest plot to determine an overall estimate of weight loss. The Potential for Methodological Bias Assessment Tool (PMBAT) was used to create a bias score for each study. Results: Overall, subjects in the placebo group lost 3.8 kg (p<0.001). Placebo subjects in the orlistat trials lost significantly more weight (4.3 kg) than did subjects in the sibutramine trials (1.1 kg, p=0.014). The subjects in the sibutramine studies did not lose a significant amount of weight (p=0.397). There were distinct differences between the sibutramine and orlistat studies with regard to nutrition and exercise interventions. The mean score on the PMBAT was 16.7 ± 3.6; and no study scored higher than 25 out of 45 total points. Conclusions: Overall subjects in the placebo group in the combined orlistat and sibutramine studies lost a significant amount of weight. Differences in study design, bias, and the Hawthorne effect may have contributed to this weight loss.


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