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dc.contributor.authorPalejwala, Sheri
dc.contributor.authorSharma, Saurabh
dc.contributor.authorLe, Christopher
dc.contributor.authorChang, Eugene
dc.contributor.authorErman, Audrey
dc.contributor.authorLemole, G.
dc.date.accessioned2017-06-23T23:49:21Z
dc.date.available2017-06-23T23:49:21Z
dc.date.issued2017-05-04
dc.identifier.citationComplex Skull Base Reconstructions in Kadish D Esthesioneuroblastoma: Case Report 2017, 78 (02):e86 Journal of Neurological Surgery Reportsen
dc.identifier.issn2193-6358
dc.identifier.issn2193-6366
dc.identifier.pmid28480156
dc.identifier.doi10.1055/s-0037-1601877
dc.identifier.urihttp://hdl.handle.net/10150/624393
dc.description.abstractIntroduction Advanced Kadish stage esthesioneuroblastoma requires more extensive resections and aggressive adjuvant therapy to obtain adequate disease-free control, which can lead to higher complication rates. We describe the case of a patient with Kadish D esthesioneuroblastoma who underwent multiple surgeries for infectious, neurologic, and wound complications, highlighting potential preventative and salvage techniques. Case Presentation A 61-year-old man who presented with a large left-sided esthesioneuroblastoma, extending into the orbit, frontal lobe, and parapharyngeal nodes. He underwent margin-free endoscopic-assisted craniofacial resection with adjuvant craniofacial and cervical radiotherapy and concomitant chemotherapy. He then returned with breakdown of his skull base reconstruction and subsequent frontal infections and ultimately received 10 surgical procedures with surgeries for infection-related issues including craniectomy and abscess evacuation. He also had surgeries for skull base reconstruction and CSF leak, repaired with vascularized and free autologous grafts and flaps, synthetic tissues, and CSF diversion. Discussion Extensive, high Kadish stage tumors necessitate radical surgical resection, radiation, and chemotherapy, which can lead to complications. Ultimately, there are several options available to surgeons, and although precautions should be taken whenever possible, risk of wound breakdown, leak, or infection should not preclude radical surgical resection and aggressive adjuvant therapies in the treatment of esthesioneuroblastoma.
dc.language.isoenen
dc.publisherGEORG THIEME VERLAG KGen
dc.relation.urlhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1601877en
dc.rights© 2017 Georg Thieme Verlag KG Stuttgart • New Yorken
dc.subjectesthesio neuroblastomaen
dc.subjectolfactory neuroblastomaen
dc.subjectskull base reconstructionen
dc.subjectcerebrospinal fluid leaken
dc.subjectpneumocephalusen
dc.subjectsinonasal malignancyen
dc.subjectcomplicationsen
dc.titleComplex Skull Base Reconstructions in Kadish D Esthesioneuroblastoma: Case Reporten
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Dept Surg, Div Neurosurgen
dc.contributor.departmentUniv Arizona, Dept Otolaryngolen
dc.identifier.journalJournal of Neurological Surgery Reportsen
dc.description.noteOpen Access Journalen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
dc.contributor.institutionDivision of Neurosurgery, Department of Surgery, University of Arizona, Tucson, Arizona, United States
dc.contributor.institutionDepartment of Otolaryngology, University of Arizona, Tucson, Arizona, United States
dc.contributor.institutionDepartment of Otolaryngology, University of Arizona, Tucson, Arizona, United States
dc.contributor.institutionDepartment of Otolaryngology, University of Arizona, Tucson, Arizona, United States
dc.contributor.institutionDepartment of Otolaryngology, University of Arizona, Tucson, Arizona, United States
dc.contributor.institutionDivision of Neurosurgery, Department of Surgery, University of Arizona, Tucson, Arizona, United States
refterms.dateFOA2018-04-25T19:07:17Z
html.description.abstractIntroduction Advanced Kadish stage esthesioneuroblastoma requires more extensive resections and aggressive adjuvant therapy to obtain adequate disease-free control, which can lead to higher complication rates. We describe the case of a patient with Kadish D esthesioneuroblastoma who underwent multiple surgeries for infectious, neurologic, and wound complications, highlighting potential preventative and salvage techniques. Case Presentation A 61-year-old man who presented with a large left-sided esthesioneuroblastoma, extending into the orbit, frontal lobe, and parapharyngeal nodes. He underwent margin-free endoscopic-assisted craniofacial resection with adjuvant craniofacial and cervical radiotherapy and concomitant chemotherapy. He then returned with breakdown of his skull base reconstruction and subsequent frontal infections and ultimately received 10 surgical procedures with surgeries for infection-related issues including craniectomy and abscess evacuation. He also had surgeries for skull base reconstruction and CSF leak, repaired with vascularized and free autologous grafts and flaps, synthetic tissues, and CSF diversion. Discussion Extensive, high Kadish stage tumors necessitate radical surgical resection, radiation, and chemotherapy, which can lead to complications. Ultimately, there are several options available to surgeons, and although precautions should be taken whenever possible, risk of wound breakdown, leak, or infection should not preclude radical surgical resection and aggressive adjuvant therapies in the treatment of esthesioneuroblastoma.


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