Quantitative magnetic resonance imaging of brain atrophy in a mouse model of Niemann-Pick type C disease
AffiliationUniv Arizona, Biomed Engn Program
Univ Arizona, Dept Pediat
Univ Arizona, Dept Mol & Cellular Biol
Univ Arizona, Inst B105
Univ Arizona, Dept Med Imaging
Univ Arizona, McKight Brain Inst
MetadataShow full item record
PublisherPUBLIC LIBRARY SCIENCE
CitationQuantitative magnetic resonance imaging of brain atrophy in a mouse model of Niemann-Pick type C disease 2017, 12 (5):e0178179 PLOS ONE
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AbstractIn vivo magnetic resonance imaging (MRI) was used to investigate regional and global brain atrophy in the neurodegenerative Niemann Pick Type C1 (NPC1) disease mouse model. Imaging experiments were conducted with the most commonly studied mouse model of NPC1 disease at early and late disease states. High-resolution in vivo images were acquired at early and late stages of the disease and analyzed with atlas-based registration to obtain measurements of twenty brain region volumes. A two-way ANOVA analysis indicated eighteen of these regions were different due to genotype and thirteen showed a significant interaction with age and genotype. The ability to measure in vivo neurodegeneration evidenced by brain atrophy adds to the ability to monitor disease progression and treatment response in the mouse model.
NoteOpen access journal.
VersionFinal published version
SponsorsNIH NIBIB [R01EB000343]