• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA Catalogs

    Statistics

    Display statistics

    Outcomes of Patients With Double-Hit Lymphoma Who Achieve First Complete Remission

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    jco.2017.72.2157.pdf
    Size:
    908.0Kb
    Format:
    PDF
    Description:
    FInal Published Version
    Download
    Author
    Landsburg, Daniel J.
    Falkiewicz, Marissa K.
    Maly, Joseph
    Blum, Kristie A.
    Howlett, Christina
    Feldman, Tatyana
    Mato, Anthony R.
    Hill, Brian T.
    Li, Shaoying
    Medeiros, L. Jeffrey
    Torka, Pallawi
    Hernandez-Ilizaliturri, Francisco
    Reddy, Nishitha M.
    Singavi, Arun
    Fenske, Timothy S.
    Chavez, Julio C.
    Kaplan, Jason B.
    Behdad, Amir
    Petrich, Adam M.
    Bast, Martin A.
    Vose, Julie M.
    Olszewski, Adam J.
    Costa, Cristiana
    Lansigan, Frederick
    Gerson, James N.
    Barta, Stefan K.
    Calzada, Oscar
    Cohen, Jonathon B.
    Lue, Jennifer K.
    Amengual, Jennifer E.
    Rivera, Xavier
    Persky, Daniel O.
    Peace, David J.
    Nathan, Sunita
    Cassaday, Ryan D.
    Show allShow less
    Affiliation
    Univ Arizona
    Issue Date
    2017-07-10
    
    Metadata
    Show full item record
    Publisher
    AMER SOC CLINICAL ONCOLOGY
    Citation
    Outcomes of Patients With Double-Hit Lymphoma Who Achieve First Complete Remission 2017, 35 (20):2260 Journal of Clinical Oncology
    Journal
    Journal of Clinical Oncology
    Rights
    © 2017 by American Society of Clinical Oncology
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    PurposePatients with double-hit lymphoma (DHL) rarely achieve long-term survival following disease relapse. Some patients with DHL undergo consolidative autologous stem-cell transplantation (autoSCT) to reduce the risk of relapse, although the benefit of this treatment strategy is unclear.MethodsPatients with DHL who achieved first complete remission following completion of front-line therapy with either rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or intensive front-line therapy, and deemed fit for autoSCT, were included. A landmark analysis was performed, with time zero defined as 3 months after completion of front-line therapy. Patients who experienced relapse before or who were not followed until that time were excluded.ResultsRelapse-free survival (RFS) and overall survival (OS) rates at 3 years were 80% and 87%, respectively, for all patients (n = 159). Three-year RFS and OS rates did not differ significantly for autoSCT (n = 62) versus non-autoSCT patients (n = 97), but 3-year RFS was inferior in patients who received R-CHOP compared with intensive therapy (56% v 88%; P = .002). Three-year RFS and OS did not differ significantly for patients in the R-CHOP or intensive therapy cohorts when analyzed by receipt of autoSCT. The median OS following relapse was 8.6 months.Conclusion In the largest reported series, to our knowledge, of patients with DHL to achieve first complete remission, consolidative autoSCT was not associated with improved 3-year RFS or OS. In addition, patients treated with R-CHOP experienced inferior 3-year RFS compared with those who received intensive front-line therapy. When considered in conjunction with reports of patients with newly diagnosed DHL, which demonstrate lower rates of disease response to R-CHOP compared with intensive front-line therapy, our findings further support the use of intensive front-line therapy for this patient population.
    Note
    6 month embargo; Published Online: May 5, 2017.
    ISSN
    0732-183X
    1527-7755
    DOI
    10.1200/JCO.2017.72.2157
    Version
    Final published version
    Sponsors
    Curis (Inst); TG Therapeutics (Inst); AbbVie (Inst); Acerta Pharma (Inst); Regeneron (Inst); DTRM (Inst); Portola Pharmaceuticals (Inst); Pharmacyclics (Inst); Karyopharm Therapeutics (Inst); Spectrum Pharmaceuticals (Inst); Seattle Genetics; Merck; Celgene; Bristol-Myers Squibb; Janssen; Novartis; Takeda; Seattle Genetics (Inst); Gilead Sciences (Inst); Merck (Inst); Incyte (Inst); Pfizer (Inst)
    Additional Links
    http://ascopubs.org/doi/10.1200/JCO.2017.72.2157
    ae974a485f413a2113503eed53cd6c53
    10.1200/JCO.2017.72.2157
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.