The Effects of Chronic Hyperinsulinemia on Systolic and Diastolic Blood Pressures in Peripubertal Children
AuthorLederer, Kayla Marie
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PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractObesity and Diabetes are intertwined in a growing epidemic called Metabolic Syndrome; a reflection of poor health and metabolic outcomes. Pre-diabetes specifically involves a period of initial insulin resistance, causing hypersecretion of the insulin hormone, which, chronically, can cause peripheral damage that ultimately leads to hypertension. Previous studies in adults have examined multiple mechanisms that mediate this potentially causal relationship between chronically elevated plasma insulin levels and elevated blood pressure. Here, we use the University of Arizona’s EPIC Kids study to apply these mechanisms to 9 to 12 year-old children with a predisposition to Type II Diabetes Mellitus. Data analysis of 47 participants suggests a potential positive correlation between HOMA-IR (a reflection of insulin resistance) and systolic blood pressure, which we propose may be due to decreased vascular compliance. This weak relationship suggests that clinical peripubertal hypertension may have the potential to play a diagnostic role for early metabolic syndrome in children, and can indicate need for further treatment.
Degree ProgramHonors College