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dc.contributor.advisorOgden, Kimberlyen
dc.contributor.authorLee, John Wonhee
dc.creatorLee, John Wonheeen
dc.date.accessioned2017-07-28T20:55:54Z
dc.date.available2017-07-28T20:55:54Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/10150/625034
dc.description.abstractThis thesis develops a process and associated plant design for the large-scale production of a rotavirus vaccine. With an estimated annual 215 000 child deaths and only 19% immunization within the population, there exists a worldwide demand for the vaccine. Among various commercial vaccines already in production, a vaccine made by GlaxoSmithKline known as Rotarix was the product ultimately chosen to model. This is due to its relatively simple manufacturing process, high effectiveness, and ease of use. The thesis first formulates the process stages necessary to manufacture the working vaccine including cell expansion, clarification, and lyophilization. It then analyzes the economic feasibility of the process using costing estimations and budgeting tables. The final model results in a plant that can annually produce 80 000 000 doses of the vaccine and meets the needs of a substantial portion of the population. The thesis found that the proposal nets a profit after a single year of sales assuming a reasonable effective interest rate of 20%, making it a highly desirable investment. The thesis concludes with suggested experiments to obtain empirical values of the virus and improve models along with recommendations on further optimizing the design.
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.titleLarge-Scale Manufacture of a Rotavirus Vaccineen_US
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.grantorUniversity of Arizonaen
thesis.degree.levelbachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineChemical Engineeringen
thesis.degree.nameB.S.en
refterms.dateFOA2018-06-28T20:40:16Z
html.description.abstractThis thesis develops a process and associated plant design for the large-scale production of a rotavirus vaccine. With an estimated annual 215 000 child deaths and only 19% immunization within the population, there exists a worldwide demand for the vaccine. Among various commercial vaccines already in production, a vaccine made by GlaxoSmithKline known as Rotarix was the product ultimately chosen to model. This is due to its relatively simple manufacturing process, high effectiveness, and ease of use. The thesis first formulates the process stages necessary to manufacture the working vaccine including cell expansion, clarification, and lyophilization. It then analyzes the economic feasibility of the process using costing estimations and budgeting tables. The final model results in a plant that can annually produce 80 000 000 doses of the vaccine and meets the needs of a substantial portion of the population. The thesis found that the proposal nets a profit after a single year of sales assuming a reasonable effective interest rate of 20%, making it a highly desirable investment. The thesis concludes with suggested experiments to obtain empirical values of the virus and improve models along with recommendations on further optimizing the design.


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