Show simple item record

dc.contributor.advisorRiggs, Michael W.en
dc.contributor.authorLeinart, Linzey Barbara
dc.creatorLeinart, Linzey Barbaraen
dc.date.accessioned2017-07-28T21:02:43Z
dc.date.available2017-07-28T21:02:43Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/10150/625036
dc.description.abstractDemodex canis mites are found in the normal skin microbiota of most dogs, but can result in canine demodicosis if the number of mites dramatically increases due to underlying disease, immunosurpression, genetic defect, stress, or breed association. Treating generalized Demodectic mange often requires high owner compliance over a potentially long period of time, especially when using ivermectin. Recent studies have revealed that a class of insecticides known as isoxasolines provide a better alternative for treatment of generalized demodicosis, specifically afoxolaner (NexGard®), fluralaner (Bravecto™), and sarolaner (Simparica™). This review compares the efficacy, side effects, and cost of isoxasolines to ivermectin in efforts to aid owners and veterinarians in choosing an effective, yet safe and lost-cost treatment option. Although additional studies are needed, fluralaner appears to be highly efficacious and the safest and cheapest treatment option for generalized canine demodicosis, while ivermectin appeared to be the least preferred treatment option presently, a major factor being toxicity.
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.titleComparison of Efficacy, Side Effects, and Cost of Isoxasolines and Ivermectin Against Generalized Canine Demodicosisen_US
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.grantorUniversity of Arizonaen
thesis.degree.levelbachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineVeterinary Scienceen
thesis.degree.nameB.S.en
refterms.dateFOA2018-06-16T18:16:29Z
html.description.abstractDemodex canis mites are found in the normal skin microbiota of most dogs, but can result in canine demodicosis if the number of mites dramatically increases due to underlying disease, immunosurpression, genetic defect, stress, or breed association. Treating generalized Demodectic mange often requires high owner compliance over a potentially long period of time, especially when using ivermectin. Recent studies have revealed that a class of insecticides known as isoxasolines provide a better alternative for treatment of generalized demodicosis, specifically afoxolaner (NexGard®), fluralaner (Bravecto™), and sarolaner (Simparica™). This review compares the efficacy, side effects, and cost of isoxasolines to ivermectin in efforts to aid owners and veterinarians in choosing an effective, yet safe and lost-cost treatment option. Although additional studies are needed, fluralaner appears to be highly efficacious and the safest and cheapest treatment option for generalized canine demodicosis, while ivermectin appeared to be the least preferred treatment option presently, a major factor being toxicity.


Files in this item

Thumbnail
Name:
azu_etd_hr_2017_0111_sip1_m.pdf
Size:
156.0Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record