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dc.contributor.advisorRance, Naomien
dc.contributor.authorMcMinn, Jessi Rae
dc.creatorMcMinn, Jessi Raeen
dc.date.accessioned2017-08-08T15:22:16Z
dc.date.available2017-08-08T15:22:16Z
dc.date.issued2017
dc.identifier.citationMcMinn, Jessi Rae. (2017). Effect of Estrogen Status on Circadian Core and Tail Skin Temperature Rhythms in Female Mice (Bachelor's thesis, University of Arizona, Tucson, USA).
dc.identifier.urihttp://hdl.handle.net/10150/625094
dc.description.abstractBody temperature in women is altered by changes in circulating gonadal steroids during the menstrual cycle and estrogen withdrawal after menopause. In contrast to numerous studies in the rat, there is limited information on the effects of estrogen on body temperature regulation in the mouse. The present studies were designed to measure circadian rhythms of core temperature (TCORE) and tail skin temperature (TSKIN) in the mouse. In experiment 1, female mice were implanted with an intraperitoneal temperature probe to measure TCORE and a temperature probe was attached to the tail to measure TSKIN. Daily vaginal smears were taken to assess estrous cycle stage and TCORE and TSKIN were measured continuously for 14 days. In experiment 2, temperature measurements were recorded for ovariectomized (OVX), and low and high estrogen (E2) replaced animals. We report circadian rhythms of TCORE and TSKIN were not affected by day of the estrous cycle. There was also no significant effect of estrogen replacement on TSKIN during the dark phase, regardless of the E2 dose. However, low and high E2 significantly decreased TCORE in OVX mice during the light phase. These studies reveal a significant species difference in estrogen modulation of thermoregulation in the rat and mouse.
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleEffect of Estrogen Status on Circadian Core and Tail Skin Temperature Rhythms in Female Miceen_US
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.grantorUniversity of Arizonaen
thesis.degree.levelbachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplinePhysiologyen
thesis.degree.nameB.S.en
refterms.dateFOA2018-06-13T05:56:22Z
html.description.abstractBody temperature in women is altered by changes in circulating gonadal steroids during the menstrual cycle and estrogen withdrawal after menopause. In contrast to numerous studies in the rat, there is limited information on the effects of estrogen on body temperature regulation in the mouse. The present studies were designed to measure circadian rhythms of core temperature (TCORE) and tail skin temperature (TSKIN) in the mouse. In experiment 1, female mice were implanted with an intraperitoneal temperature probe to measure TCORE and a temperature probe was attached to the tail to measure TSKIN. Daily vaginal smears were taken to assess estrous cycle stage and TCORE and TSKIN were measured continuously for 14 days. In experiment 2, temperature measurements were recorded for ovariectomized (OVX), and low and high estrogen (E2) replaced animals. We report circadian rhythms of TCORE and TSKIN were not affected by day of the estrous cycle. There was also no significant effect of estrogen replacement on TSKIN during the dark phase, regardless of the E2 dose. However, low and high E2 significantly decreased TCORE in OVX mice during the light phase. These studies reveal a significant species difference in estrogen modulation of thermoregulation in the rat and mouse.


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