Show simple item record

dc.contributor.authorLines, Justin
dc.contributor.authorNation, Kelsey
dc.contributor.authorFellous, Jean-Marc
dc.date.accessioned2017-08-10T16:01:05Z
dc.date.available2017-08-10T16:01:05Z
dc.date.issued2017
dc.identifier.citationDorsoventral and Proximodistal Hippocampal Processing Account for the Influences of Sleep and Context on Memory (Re)consolidation: A Connectionist Model 2017, 2017:1 Computational Intelligence and Neuroscienceen
dc.identifier.issn1687-5265
dc.identifier.issn1687-5273
dc.identifier.doi10.1155/2017/8091780
dc.identifier.urihttp://hdl.handle.net/10150/625218
dc.description.abstractThe context in which learning occurs is sufficient to reconsolidate stored memories and neuronal reactivation may be crucial to memory consolidation during sleep. The mechanisms of context-dependent and sleep-dependent memory (re)consolidation are unknown but involve the hippocampus. We simulated memory (re)consolidation using a connectionist model of the hippocampus that explicitly accounted for its dorsoventral organization and for CA1 proximodistal processing. Replicating human and rodent (re)consolidation studies yielded the following results. (1) Semantic overlap between memory items and extraneous learning was necessary to explain experimental data and depended crucially on the recurrent networks of dorsal but not ventral CA3. (2) Stimulus-free, sleep-induced internal reactivations of memory patterns produced heterogeneous recruitment of memory items and protected memories from subsequent interference. These simulations further suggested that the decrease in memory resilience when subjects were not allowed to sleep following learning was primarily due to extraneous learning. (3) Partial exposure to the learning context during simulated sleep (i.e., targeted memory reactivation) uniformly increased memory item reactivation and enhanced subsequent recall. Altogether, these results show that the dorsoventral and proximodistal organization of the hippocampus may be important components of the neural mechanisms for context-based and sleep-based memory (re)consolidations.
dc.language.isoenen
dc.publisherHINDAWI LTDen
dc.relation.urlhttps://www.hindawi.com/journals/cin/2017/8091780/en
dc.rightsCopyright © 2017 Justin Lines et al. This is an open access article distributed under the Creative Commons Attribution License.en
dc.titleDorsoventral and Proximodistal Hippocampal Processing Account for the Influences of Sleep and Context on Memory (Re)consolidation: A Connectionist Modelen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Dept Psycholen
dc.contributor.departmentUniv Arizona, Neurosci Grad Interdisciplinary Programen
dc.contributor.departmentUniv Arizona, Program Appl Mathen
dc.identifier.journalComputational Intelligence and Neuroscienceen
dc.description.noteOpen Access Journal.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
dc.contributor.institutionDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA
dc.contributor.institutionNeuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ 85721, USA
dc.contributor.institutionDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA
refterms.dateFOA2018-09-11T22:09:13Z
html.description.abstractThe context in which learning occurs is sufficient to reconsolidate stored memories and neuronal reactivation may be crucial to memory consolidation during sleep. The mechanisms of context-dependent and sleep-dependent memory (re)consolidation are unknown but involve the hippocampus. We simulated memory (re)consolidation using a connectionist model of the hippocampus that explicitly accounted for its dorsoventral organization and for CA1 proximodistal processing. Replicating human and rodent (re)consolidation studies yielded the following results. (1) Semantic overlap between memory items and extraneous learning was necessary to explain experimental data and depended crucially on the recurrent networks of dorsal but not ventral CA3. (2) Stimulus-free, sleep-induced internal reactivations of memory patterns produced heterogeneous recruitment of memory items and protected memories from subsequent interference. These simulations further suggested that the decrease in memory resilience when subjects were not allowed to sleep following learning was primarily due to extraneous learning. (3) Partial exposure to the learning context during simulated sleep (i.e., targeted memory reactivation) uniformly increased memory item reactivation and enhanced subsequent recall. Altogether, these results show that the dorsoventral and proximodistal organization of the hippocampus may be important components of the neural mechanisms for context-based and sleep-based memory (re)consolidations.


Files in this item

Thumbnail
Name:
8091780.pdf
Size:
2.746Mb
Format:
PDF
Description:
FInal Published Version

This item appears in the following Collection(s)

Show simple item record