CREATING HIGH-VALUE REAL-WORLD IMPACT THROUGH SYSTEMATIC PROGRAMS OF RESEARCH
AffiliationUniv Arizona, Eller Coll Management
IS research methodology
value of IS research
systematic high-impact research model
MetadataShow full item record
PublisherSOC INFORM MANAGE-MIS RES CENT
CitationNunamaker, J. F., Twyman, N. W., Giboney, J. S., & Briggs, R. O. (2017). CREATING HIGH-VALUE REAL-WORLD IMPACT THROUGH SYSTEMATIC PROGRAMS OF RESEARCH. MIS Quarterly, 41(2), 335-351.
RightsCopyright © of MIS Quarterly.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractAn ongoing conversation in the Information Systems literature addresses the concern, "How can we conduct research that makes a difference?" A shortage of high-impact research will, over time, challenge the identity and weaken the viability of IS as an academic discipline. This paper presents the systematic high-impact research model (SHIR), an approach to conducting high-impact research. SHIR embodies the insight gained from three streams of high-impact research programs spanning more than 50 years. The SHIR framework rests on the proposition that IS researchers can produce higher-impact contributions by developing long-term research programs around major real-world issues, as opposed to ad hoc projects addressing a small piece of a large problem. These persistent research programs focus on addressing the entirety of an issue, by leveraging multidisciplinary, multiuniversity research centers that employ a breadth of research methods and large-scale projects. To function effectively, SHIR programs must be sustained by academic and practitioner partnerships, research centers, and outreach activities. We argue that SHIR research programs increase the likelihood of high impact research.
Note60 month embargo; Published online: June 2017
VersionFinal published version
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Pineal-mediated inhibition of prolactin cell activity: Investigation of dopaminergic involvement.Burns, Danny Michael. (The University of Arizona., 1989)The purpose of these studies was to determine whether the inhibitory effects of short photoperiod exposure on prolactin cell activity in male Syrian hamsters and/or the inhibitory effects of melatonin treatment on the growth and activity of diethylstilbestrol- (DES) induced prolactinomas in Fisher 344 (F344) rats were possibly mediated through alterations in dopaminergic regulatory mechanisms. In both the hamster and the rat, changes in hypothalamic dopamine neuronal activity and changes in pituitary responsiveness to dopamine have been suggested as possible mechanisms in the prolactin-inhibitory effects of light deprivation or melatonin administration. The present studies in the male Syrian hamster addressed two issues. First, it was of interest to determine if anterior pituitaries of long photoperiod-exposed male hamsters possess dopamine receptors, which are presumably necessary for responsiveness to dopamine. This was accomplished by analysis of ³H-spiperone binding to anterior pituitary membranes. Second, possible changes in pituitary sensitivity to dopamine were assessed by comparison of dose response curves for the inhibition by dopamine of prolactin release from hemipituitaries incubated in vitro from both long and short photoperiod-exposed animals over a series of time points from three to fifteen weeks. In the second series of experiments, adult female F344 rats received daily injection of melatonin or saline vehicle. After two weeks, half of the animals were sacrificed for analysis of ³H-spiperone binding to anterior pituitary membranes, measurement of hypothalamic dopamine turnover and analysis of in vitro pituitary sensitivity to dopamine. The remaining animals received subcutaneous implants containing DES and injections were continued on the same schedule until sacrifice four weeks later for measurement of the same parameters. In both the hamster and rat models, treatments exerted profound inhibitory effects on indices of prolactin cell activity. However, these studies provide no evidence for the involvement of altered dopaminergic regulation in the production of such effects. Neither pituitary sensitivity to dopamine in vitro nor hypothalamic dopamine neuronal activity was enhanced by short photoperiod exposure or melatonin treatment. Prolactin-inhibitory effects of these treatments appear to be mediated through as yet unidentified dopamine-independent mechanisms.
Synthesis and biological activities of tachykinin and opioid-related compounds, synthesis of unusual amino acids, and the investigations into the smooth muscle pharmacology of tachykinins.Hruby, Victor J.; Landis, Geoffrey Carrothers.; Bates, Robert B.; O'Brien, David F.; Kreulen, David L.; Burks, Thomas F. (The University of Arizona., 1989)Eight cyclic analogues of Substance P were made in order to investigate the conformation of the C-terminal end of the peptide. These analogues were designed to test three literature models describing the active conformation of substance P. Although the potencies of the analogues were low (in the micromolar range), our results support Cotrait's and Hospital's model (1986). Several substance P antagonists were synthesized. These compounds did not demonstrate agonistic activity nor anatagonistic activity. The tryptophan side chain is contributing to the antagonistic activity of these analogues, and not just the chirality of the α-carbon. Highly potent and selective photoaffinity ligands of H-Tyr-D-Pen-Gly-Phe-D-Pen-OH (DPDPE) and D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH₂ (CTP) were synthesized. These compounds will be useful in the isolation of δ and μ opioid receptors. Several new amino acids designed and synthesized to contain both the natural amino acid side chain and a thiol group which can be used to make disulfide constraints. The racemic amino acids made were as follows: (1) 2-amino-4-methyl-2- [(p-methylbenzyl)thiomethyl] pentanoic acid; (2) 2-amino-2- [(p-methylbenzyl)thiomethyl] -3-phenylpropanoic acid; (3) 2-amino-e- [(p-methylbenzyl)thio] pentanoic acid; and (4) 2-amino-3- [(p-methylbenzyl)-thio] -3-phenyl-pentanoic acid. These amino acids will be useful in the conformational restriction of peptides. To investigate the δ-opioid receptor conformation proposed for DPDPE by Hruby et al. (1988) and the μ-opioid receptor conformation proposed for Tyr-c [Abu₂,Gly,Phe,Leu] by Mierke et al. (1988), constrained phenylalanine amino acids were incorporated into H-Try-D-Pen-Gly-Phe-D-Pen-OH (DPDPE) in the four position. Our results indicate that these models are correct. And in an investigation into the physical-chemical properties of the delta opioid receptor, our results suggest that the δ receptor topochemical site for the Phe⁴ residue contains a partial positive charge on its surface and has specific steric requirements.
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