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dc.contributor.authorHowarth, Ashley L.
dc.contributor.authorNiska, Joshua R.
dc.contributor.authorBrooks, Kenneth
dc.contributor.authorAnand, Aman
dc.contributor.authorBues, Martin
dc.contributor.authorVargas, Carlos E.
dc.contributor.authorMahabir, Raman C.
dc.date.accessioned2017-08-25T20:34:34Z
dc.date.available2017-08-25T20:34:34Z
dc.date.issued2017-06
dc.identifier.citationTissue Expanders and Proton Beam Radiotherapy 2017, 5 (6):e1390 Plastic and Reconstructive Surgery - Global Openen
dc.identifier.issn2169-7574
dc.identifier.doi10.1097/GOX.0000000000001390
dc.identifier.urihttp://hdl.handle.net/10150/625389
dc.description.abstractProton beam radiotherapy (PBR) has gained acceptance for the treatment of breast cancer because of unique beam characteristics that allow superior dose distributions with optimal dose to the target and limited collateral damage to adjacent normal tissue, especially to the heart and lungs. To determine the compatibility of breast tissue expanders (TEs) with PBR, we evaluated the structural and dosimetric properties of 2 ex vivo models: 1 model with internal struts and another model without an internal structure. Although the struts appeared to have minimal impact, we found that the metal TE port alters PBR dynamics, which may increase proton beam range uncertainty. Therefore, submuscular TE placement may be preferable to subcutaneous TE placement to reduce the interaction of the TE and proton beam. This will reduce range uncertainty and allow for more ideal radiation dose distribution.
dc.language.isoenen
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen
dc.relation.urlhttp://Insights.ovid.com/crossref?an=01720096-201706000-00022en
dc.rightsCopyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND).en
dc.titleTissue Expanders and Proton Beam Radiotherapyen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Coll Meden
dc.identifier.journalPlastic and Reconstructive Surgery - Global Openen
dc.description.noteOpen access journal.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
refterms.dateFOA2018-09-11T22:34:38Z
html.description.abstractProton beam radiotherapy (PBR) has gained acceptance for the treatment of breast cancer because of unique beam characteristics that allow superior dose distributions with optimal dose to the target and limited collateral damage to adjacent normal tissue, especially to the heart and lungs. To determine the compatibility of breast tissue expanders (TEs) with PBR, we evaluated the structural and dosimetric properties of 2 ex vivo models: 1 model with internal struts and another model without an internal structure. Although the struts appeared to have minimal impact, we found that the metal TE port alters PBR dynamics, which may increase proton beam range uncertainty. Therefore, submuscular TE placement may be preferable to subcutaneous TE placement to reduce the interaction of the TE and proton beam. This will reduce range uncertainty and allow for more ideal radiation dose distribution.


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